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STR3 cystathionine beta-lyase STR3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852691, updated on 13-Apr-2024

Summary

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Gene symbol
STR3
Gene description
cystathionine beta-lyase STR3
Primary source
SGD:S000003152
Locus tag
YGL184C
See related
AllianceGenome:SGD:S000003152
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables cystathionine beta-lyase activity and cysteine-S-conjugate beta-lyase activity. Involved in methionine biosynthetic process and transsulfuration. Located in peroxisome. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and cystathioninuria. Orthologous to human CTH (cystathionine gamma-lyase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See STR3 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (154615..156012, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Tpn1p Neighboring gene putative hydroxyacid dehydrogenase Neighboring gene Mnd1p Neighboring gene Gts1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Engineering Saccharomyces cerevisiae to release 3-Mercaptohexan-1-ol during fermentation through overexpression of an S. cerevisiae Gene, STR3, for improvement of wine aroma. Holt S, et al. Appl Environ Microbiol, 2011 Jun. PMID 21478306, Free PMC Article
  2. Identification of peroxisomal membrane proteins of Saccharomyces cerevisiae by mass spectrometry. Schäfer H, et al. Electrophoresis, 2001 Aug. PMID 11565790
  3. Generation of 2-Furfurylthiol by Carbon-Sulfur Lyase from the Baijiu Yeast Saccharomyces cerevisiae G20. Zha M, et al. J Agric Food Chem, 2018 Mar 7. PMID 29436228
  4. STR3 and CYS3 Contribute to 2-Furfurylthiol Biosynthesis in Chinese Sesame-Flavored Baijiu Yeast. Zha M, et al. J Agric Food Chem, 2017 Jul 12. PMID 28603986
  5. Acrolein-stressed threshold adaptation alters the molecular and metabolic bases of an engineered Saccharomyces cerevisiae to improve glutathione production. Zhou W, et al. Sci Rep, 2018 Mar 14. PMID 29540749, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables carbon-sulfur lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cystathionine beta-lyase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cystathionine beta-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables cystathionine beta-lyase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables cystathionine beta-lyase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables cysteine-S-conjugate beta-lyase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cysteine-S-conjugate beta-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables pyridoxal phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 'de novo' L-methionine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in methionine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in methionine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transsulfuration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transsulfuration IEA
Inferred from Electronic Annotation
more info
  
involved_in transsulfuration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cystathionine beta-lyase STR3
NP_011331.3
  • Peroxisomal cystathionine beta-lyase; converts cystathionine into homocysteine; may be redox regulated by Gto1p; involved in the release of the aromatic thiol 3-mercaptohexanol during wine fermentation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    154615..156012 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181049.3 → NP_011331.3  TPA: cystathionine beta-lyase STR3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011331.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTX0, P53101
    UniProtKB/TrEMBL
    A0A8H4F9T1, A6ZU04, C7GX10, C8Z868, E3VL26, N1P4L6
    Conserved Domains (1) summary
    TIGR01329
    Location:6 → 409
    cysta_beta_ly_E; cystathionine beta-lyase, eukaryotic
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53101.1

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