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TAF6 TATA-binding protein-associated factor TAF6 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852766, updated on 13-Apr-2024

Summary

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Gene symbol
TAF6
Gene description
TATA-binding protein-associated factor TAF6
Primary source
SGD:S000003080
Locus tag
YGL112C
See related
AllianceGenome:SGD:S000003080
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
TAF60
Summary
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; chromatin binding activity; and molecular adaptor activity. Involved in several processes, including RNA polymerase II preinitiation complex assembly; histone acetylation; and positive regulation of DNA-templated transcription, initiation. Located in cytosol and nucleus. Part of SAGA complex; SLIK (SAGA-like) complex; and transcription factor TFIID complex. Orthologous to several human genes including TAF6 (TATA-box binding protein associated factor 6). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (298178..299728, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Sld3p Neighboring gene ribosome biosynthesis protein NSA1 Neighboring gene Cue3p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Synergistic and promoter-selective activation of transcription by recruitment of transcription factors TFIID and TFIIB. Gonzalez-Couto E, et al. Proc Natl Acad Sci U S A, 1997 Jul 22. PMID 9223310, Free PMC Article
  2. Molecular and genetic characterization of a Taf1p domain essential for yeast TFIID assembly. Singh MV, et al. Mol Cell Biol, 2004 Jun. PMID 15143185, Free PMC Article
  3. Use of a genetically introduced cross-linker to identify interaction sites of acidic activators within native transcription factor IID and SAGA. Klein J, et al. J Biol Chem, 2003 Feb 28. PMID 12501245
  4. A histone fold TAF octamer within the yeast TFIID transcriptional coactivator. Selleck W, et al. Nat Struct Biol, 2001 Aug. PMID 11473260
  5. Activator-independent functions of the yeast mediator sin4 complex in preinitiation complex formation and transcription reinitiation. Reeves WM, et al. Mol Cell Biol, 2003 Jan. PMID 12482986, Free PMC Article

See all (142) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results indicate that HEAT domain and the histone H4-like histone-fold domain (HFD) in TAF6 are required for transcriptional activation.
    Title: Mutational analysis of TAF6 revealed the essential requirement of the histone-fold domain and the HEAT repeat domain for transcriptional activation.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to RNA polymerase II general transcription initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II general transcription initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II-specific DNA-binding transcription factor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables molecular adaptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA polymerase II preinitiation complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription initiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription initiation at RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of SAGA complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SAGA complex IEA
Inferred from Electronic Annotation
more info
  
part_of SLIK (SAGA-like) complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SLIK (SAGA-like) complex IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIID complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIID complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription factor TFIID complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
TATA-binding protein-associated factor TAF6
NP_011403.1
  • Subunit (60 kDa) of TFIID and SAGA complexes; involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4; relocalizes to the cytosol in response to hypoxia

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    298178..299728 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180977.1 → NP_011403.1  TPA: TATA-binding protein-associated factor TAF6 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011403.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VU35, P53040
    UniProtKB/TrEMBL
    A0A6A5PY20, A6ZU70, B3LHH5, C7GM06, C8Z8D8, N1P9P2
    Conserved Domains (1) summary
    COG5095
    Location:6 → 513
    TAF6; Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA) [Transcription]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
6T9I_E.1
6T9K_E.1
P53040.1

Gene LinkOut

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