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GUP1 O-acyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 852796, updated on 5-May-2024

Summary

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Gene symbol
GUP1
Gene description
O-acyltransferase
Primary source
SGD:S000003052
Locus tag
YGL084C
See related
AllianceGenome:SGD:S000003052
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables O-acyltransferase activity. Involved in GPI anchor biosynthetic process; glycerol catabolic process; and glycerol transport. Located in endoplasmic reticulum and plasma membrane. Human ortholog(s) of this gene implicated in chondrodysplasia-pseudohermaphroditism syndrome. Orthologous to human HHAT (hedgehog acyltransferase) and HHATL (hedgehog acyltransferase like). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (350616..352298, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene coiled-coil domain-containing protein MAD1 Neighboring gene Lcl3p Neighboring gene Scy1p Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Quantitative differential proteomics of yeast extracellular matrix: there is more to it than meets the eye. Faria-Oliveira F, et al. BMC Microbiol, 2015 Nov 25. PMID 26608260, Free PMC Article
  2. Programmed cell death in Saccharomyces cerevisiae is hampered by the deletion of GUP1 gene. Tulha J, et al. BMC Microbiol, 2012 May 22. PMID 22617017, Free PMC Article
  3. The yeast O-acyltransferase Gup1p interferes in lipid metabolism with direct consequences on the sphingolipid-sterol-ordered domains integrity/assembly. Ferreira C, et al. Biochim Biophys Acta, 2008 Nov. PMID 18786505
  4. The Gup1 homologue of Trypanosoma brucei is a GPI glycosylphosphatidylinositol remodelase. Jaquenoud M, et al. Mol Microbiol, 2008 Jan. PMID 18036137
  5. GUP1 of Saccharomyces cerevisiae encodes an O-acyltransferase involved in remodeling of the GPI anchor. Bosson R, et al. Mol Biol Cell, 2006 Jun. PMID 16597698, Free PMC Article

See all (90) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. As a first step toward identifying the actual molecular/enzymatic function of Gup1, this work identified by co-immunoprecipitation the yeast mitochondria membrane VDAC1/Por1 as a physical partner of Gup1.
    Title: Saccharomyces cerevisiae mitochondrial Por1/yVDAC1 (voltage-dependent anion channel 1) interacts physically with the MBOAT O-acyltransferase Gup1/HHATL in the control of cell wall integrity and programmed cell death.
  2. Cells lacking GUP1 are not capable of undergoing apoptosis but instead appear to be experiencing a necrotic cell death process, upon both chronological aging and acetic acid induction.
    Title: Programmed cell death in Saccharomyces cerevisiae is hampered by the deletion of GUP1 gene.
  3. Gup1p is involved in lipid metabolism and shows the direct consequences of its absence on the plasma membrane sphingolipid-sterol-ordered domains integrity/assembly.
    Title: The yeast O-acyltransferase Gup1p interferes in lipid metabolism with direct consequences on the sphingolipid-sterol-ordered domains integrity/assembly.
  4. GUP1 function depends on the active site histidine and is highly conserved among fungi and protozoa.
    Title: GUP1 of Saccharomyces cerevisiae encodes an O-acyltransferase involved in remodeling of the GPI anchor.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables O-acyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in GPI anchor biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glycerol catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glycerol transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
O-acyltransferase
NP_011431.1
  • Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; role in misfolded protein quality control; proposed to be involved in glycerol transport; homolog of the mammalian Hedgehog pathway modulator HHATL; GUP1 has a paralog, GUP2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    350616..352298 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180949.1 → NP_011431.1  TPA: O-acyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011431.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VU60, P53154
    UniProtKB/TrEMBL
    A0A6V8RLN6, A6ZU95, B3LHF0, B5VIP0, C7GW32, C8Z8G4
    Conserved Domains (1) summary
    COG1696
    Location:39 → 560
    DltB; D-alanyl-lipoteichoic acid acyltransferase DltB, MBOAT superfamily [Cell wall/membrane/envelope biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53154.1

Gene LinkOut

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