NPY1 NAD(+) diphosphatase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: NPY1
Gene description: NAD(+) diphosphatase
Primary source: FungiDB:YGL067W
Locus tag: YGL067W
See related: SGD:S000003035; AllianceGenome:SGD:S000003035
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables NAD+ diphosphatase activity. Involved in NADH metabolic process. Located in peroxisome. Orthologous to several human genes including NUDT12 (nudix hydrolase 12). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See NPY1 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (376101..377255)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables NAD+ diphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables NAD+ diphosphatase activity	IEA Inferred from Electronic Annotation more info
enables NADH pyrophosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NADH pyrophosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA NAD-cap (NMN-forming) hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in NAD catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within NAD-cap decapping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in NADH metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in NADH metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in NADP catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within RNA decapping	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytosol	HDA more info	PubMed
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: NAD(+) diphosphatase

NP_011448.3

EC 3.6.1.22

NADH diphosphatase (pyrophosphatase); hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes; enzymatic component of one of several partly redundant surveillance pathways involved in decapping of non-canonical nicotinamide adenine dinucleotide (NAD) capped nuclear mRNAs (NAD-RNAs); also possesses deCoAping activity involved in the decapping of non-canonical dephospho-CoA capped RNA (dpCoA-RNA); nudix hydrolase family member

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

376101..377255

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180932.3 → NP_011448.3 TPA: NAD(+) diphosphatase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011448.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VU74, E9P928, P53164

UniProtKB/TrEMBL

A6ZUA9, B3LHD6, C8Z8H9, N1P372

Conserved Domains (1) summary

COG2816
Location:13 → 371

NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]