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PUS2 pseudouridine synthase PUS2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852817, updated on 4-Jan-2025

Summary

Official Symbol
PUS2
Official Full Name
pseudouridine synthase PUS2
Primary source
SGD:S000003031
Locus tag
YGL063W
See related
AllianceGenome:SGD:S000003031; FungiDB:YGL063W; VEuPathDB:YGL063W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables pseudouridine synthase activity. Involved in mRNA pseudouridine synthesis and tRNA pseudouridine synthesis. Located in mitochondrion. Human ortholog(s) of this gene implicated in myopathy, lactic acidosis, and sideroblastic anemia 1. Orthologous to human PUS1 (pseudouridine synthase 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See PUS2 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (383654..384766)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene GDP-Man:Man(1)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase Neighboring gene ATP-dependent RNA helicase Neighboring gene pyruvate carboxylase 1 Neighboring gene Duo1p

Interactions

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding  
enables isomerase activity  
enables mitochondrial tRNA pseudouridine(27/28) synthase activity  
enables pseudouridine synthase activity  
enables pseudouridine synthase activity  
enables pseudouridine synthase activity PubMed 
enables pseudouridine synthase activity PubMed 
Process Evidence Code Pubs
involved_in mRNA pseudouridine synthesis  
involved_in mRNA pseudouridine synthesis PubMed 
involved_in tRNA processing  
involved_in tRNA pseudouridine synthesis  
involved_in tRNA pseudouridine synthesis  
involved_in tRNA pseudouridine synthesis PubMed 
involved_in tRNA pseudouridine synthesis PubMed 
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle  
located_in mitochondrion PubMed 
located_in mitochondrion  
is_active_in nucleus  

General protein information

Preferred Names
pseudouridine synthase PUS2
NP_011452.4
  • Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification; mutation also affects pseudouridylation of some nuclear-encoded mRNAs; PUS2 has a paralog, PUS1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    383654..384766
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180928.4NP_011452.4  TPA: pseudouridine synthase PUS2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011452.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VU78, P53167, Q06713
    UniProtKB/TrEMBL
    A6ZUB3, B3LHD2, C7GW47, C8Z8I3, N1P5H6
    Conserved Domains (1) summary
    cd02568
    Location:1308
    PseudoU_synth_PUS1_PUS2; Pseudouridine synthase, PUS1/ PUS2 like
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