LEU1 3-isopropylmalate dehydratase LEU1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: LEU1
Gene description: 3-isopropylmalate dehydratase LEU1
Primary source: SGD:S000002977
Locus tag: YGL009C
See related: AllianceGenome:SGD:S000002977
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables 3-isopropylmalate dehydratase activity. Involved in leucine biosynthetic process. Located in cytosol. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human ACO1 (aconitase 1) and IREB2 (iron responsive element binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (476313..478652, complement)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Essential mitochondrial role in iron-sulfur cluster assembly of the cytoplasmic isopropylmalate isomerase Leu1 in Saccharomyces cerevisiae.
Title: Essential mitochondrial role in iron-sulfur cluster assembly of the cytoplasmic isopropylmalate isomerase Leu1 in Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 3-isopropylmalate dehydratase activity	IEA Inferred from Electronic Annotation more info
enables 3-isopropylmalate dehydratase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-leucine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in L-leucine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in alpha-amino acid biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of 3-isopropylmalate dehydratase complex	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic stress granule	HDA more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: 3-isopropylmalate dehydratase LEU1

NP_011506.1

EC 4.2.1.33

Isopropylmalate isomerase; catalyzes the second step in the leucine biosynthesis pathway

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

476313..478652 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180874.1 → NP_011506.1 TPA: 3-isopropylmalate dehydratase LEU1 [Saccharomyces cerevisiae S288C]

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VUC8, P07264

UniProtKB/TrEMBL

A0A8H4C1J3, G2WE84, N1P9T2

Conserved Domains (2) summary

TIGR00171
Location:545 → 736

leuD; 3-isopropylmalate dehydratase, small subunit

PRK05478
Location:9 → 480

PRK05478; 3-isopropylmalate dehydratase large subunit