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ACB1 long-chain fatty acid transporter ACB1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852925, updated on 4-Feb-2024

Summary

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Gene symbol
ACB1
Gene description
long-chain fatty acid transporter ACB1
Primary source
SGD:S000003269
Locus tag
YGR037C
See related
AllianceGenome:SGD:S000003269
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables long-chain fatty acyl-CoA binding activity. Involved in very long-chain fatty acid biosynthetic process. Located in extracellular region. Orthologous to several human genes including DBI (diazepam binding inhibitor, acyl-CoA binding protein). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (559731..559994, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene dolichyldiphosphatase Neighboring gene sphingolipid homeostasis protein ORM1 Neighboring gene tRNA-Ser

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Reactive oxygen species triggers unconventional secretion of antioxidants and Acb1. Cruz-Garcia D, et al. J Cell Biol, 2020 Apr 6. PMID 32328640, Free PMC Article
  2. Acyl-CoA-binding protein (ACBP): a phylogenetically conserved appetite stimulator. Charmpilas N, et al. Cell Death Dis, 2020 Jan 6. PMID 31907349, Free PMC Article
  3. Transcriptional regulation of phospholipid biosynthesis is linked to fatty acid metabolism by an acyl-CoA-binding-protein-dependent mechanism in Saccharomyces cerevisiae. Feddersen S, et al. Biochem J, 2007 Oct 15. PMID 17593018, Free PMC Article
  4. Depletion of acyl-coenzyme A-binding protein affects sphingolipid synthesis and causes vesicle accumulation and membrane defects in Saccharomyces cerevisiae. Gaigg B, et al. Mol Biol Cell, 2001 Apr. PMID 11294913, Free PMC Article
  5. Saccharomyces carlsbergensis contains two functional genes encoding the acyl-CoA binding protein, one similar to the ACB1 gene from S. cerevisiae and one identical to the ACB1 gene from S. monacensis. Børsting C, et al. Yeast, 1997 Dec. PMID 9434347

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Reactive oxygen species triggers unconventional secretion of antioxidants and Acb1.
    Title: Reactive oxygen species triggers unconventional secretion of antioxidants and Acb1.
  2. The major ESCRT-III subunit Snf7 localizes transiently to vesicles and tubules surrounded by a cup-shaped membrane and this was accelerated in vps4Delta cells, correlating with increased Acb1 secretion.
    Title: ESCRT-III drives the final stages of CUPS maturation for unconventional protein secretion.
  3. These experiments reveal a unique secretory pathway where autophagosomes containing Acb1 evade fusion with the vacuole to prevent cargo degradation.
    Title: Unconventional secretion of Acb1 is mediated by autophagosomes.
  4. study of the cardiolipin species profile in Saccharomyces cerevisiae by using depletion of the acyl-CoA-binding protein Acb1p
    Title: Cardiolipin molecular species with shorter acyl chains accumulate in Saccharomyces cerevisiae mutants lacking the acyl coenzyme A-binding protein Acb1p: new insights into acyl chain remodeling of cardiolipin.
  5. phospholipid biosynthesis gene expression is modulated either by the Acb1p-acyl-CoA ester complex directly or by its ability to donate acyl-CoA esters to utilizing systems.
    Title: Transcriptional regulation of phospholipid biosynthesis is linked to fatty acid metabolism by an acyl-CoA-binding-protein-dependent mechanism in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables fatty-acyl-CoA binding IEA
Inferred from Electronic Annotation
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables long-chain fatty acyl-CoA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables long-chain fatty acyl-CoA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in very long-chain fatty acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytosol HDA PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
long-chain fatty acid transporter ACB1
NP_011551.3
  • Acyl-CoA-binding protein; transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    559731..559994 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181166.3 → NP_011551.3  TPA: long-chain fatty acid transporter ACB1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011551.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUH4, P31787, Q45U46
    UniProtKB/TrEMBL
    A0A6A5PZ27, A6ZV26, B3LII3, C7GKA4, C8Z8T3, G2WEC8, N1P3G4
    Conserved Domains (1) summary
    COG4281
    Location:1 → 87
    ACB; Acyl-CoA-binding protein [Lipid transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P31787.3

Gene LinkOut

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