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MUP1 Mup1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852946, updated on 17-May-2024

Summary

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Gene symbol
MUP1
Gene description
Mup1p
Primary source
FungiDB:YGR055W
Locus tag
YGR055W
See related
SGD:S000003287; AllianceGenome:SGD:S000003287
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables L-methionine secondary active transmembrane transporter activity. Involved in methionine import across plasma membrane. Located in plasma membrane. Human ortholog(s) of this gene implicated in cystinuria and lysinuric protein intolerance. Orthologous to several human genes including SLC7A5 (solute carrier family 7 member 5); SLC7A6 (solute carrier family 7 member 6); and SLC7A7 (solute carrier family 7 member 7). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (599417..601141)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Mco32p Neighboring gene uncharacterized protein Neighboring gene RSC subunit protein RSC1 Neighboring gene Lst7p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Clioquinol promotes the degradation of metal-dependent amyloid-β (Aβ) oligomers to restore endocytosis and ameliorate Aβ toxicity. Matlack KE, et al. Proc Natl Acad Sci U S A, 2014 Mar 18. PMID 24591589, Free PMC Article
  2. MUP1, high affinity methionine permease, is involved in cysteine uptake by Saccharomyces cerevisiae. Kosugi A, et al. Biosci Biotechnol Biochem, 2001 Mar. PMID 11330701
  3. Applications of pHluorin for Quantitative, Kinetic and High-throughput Analysis of Endocytosis in Budding Yeast. Prosser DC, et al. J Vis Exp, 2016 Oct 23. PMID 27805610, Free PMC Article
  4. Mutation of high-affinity methionine permease contributes to selenomethionyl protein production in Saccharomyces cerevisiae. Kitajima T, et al. Appl Environ Microbiol, 2010 Oct. PMID 20693451, Free PMC Article
  5. The C-terminal region of the yeast monocarboxylate transporter Jen1 acts as a glucose signal-responding degron recognized by the α-arrestin Rod1. Fujita S, et al. J Biol Chem, 2018 Jul 13. PMID 29789424, Free PMC Article

See all (69) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-methionine secondary active transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-alpha-amino acid transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in methionine import across plasma membrane IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in methionine import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sulfur amino acid transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in fungal-type vacuole HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Mup1p
NP_011569.1
  • High affinity methionine permease; integral membrane protein with 13 putative membrane-spanning regions; involved in both methionine and cysteine uptake; subject to transport-activity dependent, methionine-induced endocytosis, vacuolar delivery and degradation; starvation-induced endocytosis is transport-activity independent

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    599417..601141
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181184.1 → NP_011569.1  TPA: Mup1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011569.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUJ0, P50276, Q45U31
    UniProtKB/TrEMBL
    A0A6V8S4S3, A6ZV40, B3LIG8, B5VJ05, C7GXN8, C8Z8U9, G2WEE2, N1P3H8
    Conserved Domains (1) summary
    TIGR00911
    Location:1 → 541
    2A0308; L-type amino acid transporter
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50276.1

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