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VAS1 valine--tRNA ligase [ Saccharomyces cerevisiae S288C ]

Gene ID: 852986, updated on 11-Apr-2024

Summary

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Gene symbol
VAS1
Gene description
valine--tRNA ligase
Primary source
SGD:S000003326
Locus tag
YGR094W
See related
AllianceGenome:SGD:S000003326
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables valine-tRNA ligase activity. Involved in valyl-tRNA aminoacylation. Located in mitochondrion. Used to study mitochondrial encephalomyopathy and mitochondrial metabolism disease. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 20. Orthologous to several human genes including VARS1 (valyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (672186..675500)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene serine/threonine-protein kinase DBF2 Neighboring gene Drn1p Neighboring gene exosome non-catalytic core subunit RRP46 Neighboring gene thiamine transporter TPC1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A tryptophan-rich peptide acts as a transcription activation domain. Lin CH, et al. BMC Mol Biol, 2010 Nov 16. PMID 21078206, Free PMC Article
  2. Mitochondrial form of a tRNA synthetase can be made bifunctional by manipulating its leader peptide. Wang CC, et al. Biochemistry, 2003 Feb 18. PMID 12578378
  3. A novel thiol-dependent arsenite-sensitive valyl-tRNA synthetase activity from yeast. Black S. J Biol Chem, 1983 Feb 25. PMID 6337152
  4. Purification and some properties of valyl ribonucleic acid synthetase from yeast. Lagerkvist U, et al. J Biol Chem, 1967 Jul 10. PMID 6027786
  5. Structure and function of transfer ribonucleic acid. II. Enzyme-substrate complexes with valyl ribonucleic acid synthetase from yeast. Lagerkvist U, et al. J Biol Chem, 1966 Nov 25. PMID 5333665

See all (73) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA editing activity IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables valine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables valine-tRNA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables valine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in aminoacyl-tRNA metabolism involved in translational fidelity IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in valyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in valyl-tRNA aminoacylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in valyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
valine--tRNA ligase
NP_011608.1
  • Mitochondrial and cytoplasmic valyl-tRNA synthetase; human homolog VARS2 implicated in mitochondrial diseases, can partially complement yeast null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    672186..675500
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181223.1 → NP_011608.1  TPA: valine--tRNA ligase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011608.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUM6, P07806
    UniProtKB/TrEMBL
    A0A8H4C319, A6ZV76, B3LID2, C7GWW9, C8Z8Y8, G2WEH9
    Conserved Domains (1) summary
    PTZ00419
    Location:128 → 1104
    PTZ00419; valyl-tRNA synthetase-like protein; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P07806.2

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