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MEP1 ammonium permease MEP1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853019, updated on 13-Apr-2024

Summary

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Gene symbol
MEP1
Gene description
ammonium permease MEP1
Primary source
SGD:S000003353
Locus tag
YGR121C
See related
AllianceGenome:SGD:S000003353
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
AMT1
Summary
Enables ammonium transmembrane transporter activity. Involved in ammonium transmembrane transport and nitrogen utilization. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (731449..732927, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Golgi transport complex subunit COG2 Neighboring gene tRNA-Asn Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dynamic copper(I) imaging in mammalian cells with a genetically encoded fluorescent copper(I) sensor. Wegner SV, et al. J Am Chem Soc, 2010 Mar 3. PMID 20131768
  2. Regulation of the high-affinity ammonium transporter (BnAMT1;2) in the leaves of Brassica napus by nitrogen status. Pearson JN, et al. Plant Mol Biol, 2002 Jul. PMID 12090624
  3. Three functional transporters for constitutive, diurnally regulated, and starvation-induced uptake of ammonium into Arabidopsis roots. Gazzarrini S, et al. Plant Cell, 1999 May. PMID 10330477, Free PMC Article
  4. Cloning and expression of the MEP1 gene encoding an ammonium transporter in Saccharomyces cerevisiae. Marini AM, et al. EMBO J, 1994 Aug 1. PMID 8062822, Free PMC Article
  5. SNPs altering ammonium transport activity of human Rhesus factors characterized by a yeast-based functional assay. Deschuyteneer A, et al. PLoS One, 2013. PMID 23967154, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. an ammonium permease MEP1-based sensing mechanism for rapid activation of the protein kinase A pathway
    Title: Ammonium permease-based sensing mechanism for rapid ammonium activation of the protein kinase A pathway in yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ammonium transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ammonium transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ammonium transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ammonium transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in ammonium transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ammonium transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in ammonium transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nitrogen utilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ammonium permease MEP1
NP_011636.3
  • Ammonium permease; belongs to Mep-Amt-Rh family of well-conserved ammonium (NH4+) transporters that includes the human Rh factors; expression is under the nitrogen catabolite repression regulation; activity regulated by TORC1 effectors, Npr1p and Par32p; human homolog RHCG complements yeast null mutant; mutations in human homolog RHCG implicated in metabolic acidosis; MEP1 has a paralog, MEP3, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    731449..732927 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181250.3 → NP_011636.3  TPA: ammonium permease MEP1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011636.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUQ2, P40260
    UniProtKB/TrEMBL
    A0A6A5PYT0, A6ZUD4, B3LIA8, B5VJ67, C7GSX1, C8Z912, G2WEK3, N1P9W6
    Conserved Domains (1) summary
    TIGR00836
    Location:19 → 424
    amt; ammonium transporter
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40260.1

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