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TPO2 spermine transporter [ Saccharomyces cerevisiae S288C ]

Gene ID: 853039, updated on 13-Apr-2024

Summary

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Gene symbol
TPO2
Gene description
spermine transporter
Primary source
SGD:S000003370
Locus tag
YGR138C
See related
AllianceGenome:SGD:S000003370
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables spermine transmembrane transporter activity. Involved in spermine transport. Located in fungal-type vacuole membrane and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (763762..765606, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene proteasome core particle subunit alpha 3 Neighboring gene Lsb1p Neighboring gene Cbf2p Neighboring gene Vps62p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Combined roles of exporters in acetic acid tolerance in Saccharomyces cerevisiae. Zhang X, et al. Biotechnol Biofuels Bioprod, 2022 Jun 18. PMID 35717394, Free PMC Article
  2. Upregulation of the Saccharomyces cerevisiae efflux pump Tpo1 rescues an Imp2 transcription factor-deficient mutant from bleomycin toxicity. Berra S, et al. Environ Mol Mutagen, 2014 Jul. PMID 24599794
  3. Quantitative analysis of the modes of growth inhibition by weak organic acids in Saccharomyces cerevisiae. Ullah A, et al. Appl Environ Microbiol, 2012 Dec. PMID 23001666, Free PMC Article
  4. Haa1, a protein homologous to the copper-regulated transcription factor Ace1, is a novel transcriptional activator. Keller G, et al. J Biol Chem, 2001 Oct 19. PMID 11504737
  5. Multiple polyamine transport systems on the vacuolar membrane in yeast. Tomitori H, et al. Biochem J, 2001 Feb 1. PMID 11171066, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables spermine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables spermine transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in spermine transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in spermine transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermine transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
is_active_in fungal-type vacuole membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fungal-type vacuole membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
spermine transporter
NP_011654.1
  • Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; TPO2 has a paralog, TPO3, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    763762..765606 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181267.1 → NP_011654.1  TPA: spermine transporter [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011654.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUR9, P53283
    UniProtKB/TrEMBL
    A0A8H4C0K8, A6ZUF1, B3LI91, B5VJ82, C8Z931
    Conserved Domains (1) summary
    cd17323
    Location:173 → 599
    MFS_Tpo1_MDR_like; Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53283.1

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