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PMT6 dolichyl-phosphate-mannose-protein mannosyltransferase PMT6 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853113, updated on 13-Apr-2024

Summary

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Gene symbol
PMT6
Gene description
dolichyl-phosphate-mannose-protein mannosyltransferase PMT6
Primary source
SGD:S000003431
Locus tag
YGR199W
See related
AllianceGenome:SGD:S000003431
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable dolichyl-phosphate-mannose-protein mannosyltransferase activity. Involved in protein O-linked mannosylation. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in lissencephaly and muscular dystrophy (multiple). Orthologous to human POMT2 (protein O-mannosyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (897502..899781)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Sng1p Neighboring gene Ypp1p Neighboring gene Elongator subunit ELP2 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. O-mannosylation is required for degradation of the endoplasmic reticulum-associated degradation substrate Gas1*p via the ubiquitin/proteasome pathway in Saccharomyces cerevisiae. Hirayama H, et al. J Biochem, 2008 Apr. PMID 18182384
  2. Protein-O-glycosylation in yeast: protein-specific mannosyltransferases. Gentzsch M, et al. Glycobiology, 1997 Jun. PMID 9184828
  3. Sequencing of a 17.6 kb segment on the right arm of yeast chromosome VII reveals 12 ORFs, including CCT, ADE3 and TR-I genes, homologues of the yeast PMT and EF1G genes, of the human and bacterial electron-transferring flavoproteins (beta-chain) and of the Escherichia coli phosphoserine phosphohydrolase, and five new ORFs. Guerreiro P, et al. Yeast, 1996 Mar 15. PMID 8904340
  4. Functional and genomic analyses of blocked protein O-mannosylation in baker's yeast. Arroyo J, et al. Mol Microbiol, 2011 Mar. PMID 21231968
  5. Genes involved in protein glycosylation determine the activity and cell internalization of the antifungal peptide PAF26 in Saccharomyces cerevisiae. Harries E, et al. Fungal Genet Biol, 2013 Sep-Oct. PMID 23942187

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables dolichyl-phosphate-mannose-protein mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dolichyl-phosphate-mannose-protein mannosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables dolichyl-phosphate-mannose-protein mannosyltransferase activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables mannosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein O-linked glycosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein O-linked glycosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein O-linked mannosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-linked mannosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dolichyl-phosphate-mannose-protein mannosyltransferase PMT6
NP_011715.1
  • Protein O-mannosyltransferase; transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    897502..899781
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181328.1 → NP_011715.1  TPA: dolichyl-phosphate-mannose-protein mannosyltransferase PMT6 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011715.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUY1, P42934
    UniProtKB/TrEMBL
    A0A8H4C1Y4, B3LI38, C7GRN1, C8Z992, N1P495
    Conserved Domains (1) summary
    COG1928
    Location:44 → 759
    PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P42934.1

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