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LSC2 succinate--CoA ligase (GDP-forming) subunit beta [ Saccharomyces cerevisiae S288C ]

Gene ID: 853159, updated on 13-Apr-2024

Summary

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Gene symbol
LSC2
Gene description
succinate--CoA ligase (GDP-forming) subunit beta
Primary source
SGD:S000003476
Locus tag
YGR244C
See related
AllianceGenome:SGD:S000003476
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables succinate-CoA ligase (ADP-forming) activity. Involved in succinyl-CoA metabolic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 5. Orthologous to human SUCLA2 (succinate-CoA ligase ADP-forming subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (978036..979319, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Yap1802p Neighboring gene mitochondrial pyruvate carrier Neighboring gene Sda1p Neighboring gene transcription factor TFIIIB subunit BRF1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genes of succinyl-CoA ligase from Saccharomyces cerevisiae. Przybyla-Zawislak B, et al. Eur J Biochem, 1998 Dec 1. PMID 9874242
  2. Synthetic rescue couples NADPH generation to metabolite overproduction in Saccharomyces cerevisiae. Partow S, et al. Metab Eng, 2017 Sep. PMID 28803913
  3. Genetic and biochemical interactions involving tricarboxylic acid cycle (TCA) function using a collection of mutants defective in all TCA cycle genes. Przybyla-Zawislak B, et al. Genetics, 1999 May. PMID 10224250, Free PMC Article
  4. Molecular genetics of yeast TCA cycle isozymes. McAlister-Henn L, et al. Prog Nucleic Acid Res Mol Biol, 1997. PMID 9175438
  5. Cardiolipin-deficient cells depend on anaplerotic pathways to ameliorate defective TCA cycle function. Raja V, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2019 May. PMID 30731133, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables succinate-CoA ligase (ADP-forming) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables succinate-CoA ligase (ADP-forming) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables succinate-CoA ligase (ADP-forming) activity IEA
Inferred from Electronic Annotation
more info
  
enables succinate-CoA ligase (ADP-forming) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in succinyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in succinyl-CoA metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in tricarboxylic acid cycle TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
part_of succinate-CoA ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
succinate--CoA ligase (GDP-forming) subunit beta
NP_011760.3
  • Beta subunit of succinyl-CoA ligase; succinyl-CoA ligase is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    978036..979319 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181373.3 → NP_011760.3  TPA: succinate--CoA ligase (GDP-forming) subunit beta [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011760.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VV24, P53312
    UniProtKB/TrEMBL
    A0A6A5Q033, A6ZUQ2, C7GNI5, C8Z9D6, G2WEX0, N1P669
    Conserved Domains (1) summary
    PRK00696
    Location:33 → 424
    sucC; ADP-forming succinate--CoA ligase subunit beta
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53312.1

Gene LinkOut

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