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ACO2 aconitate hydratase ACO2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853230, updated on 17-May-2024

Summary

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Gene symbol
ACO2
Gene description
aconitate hydratase ACO2
Primary source
FungiDB:YJL200C
Locus tag
YJL200C
See related
SGD:S000003736; AllianceGenome:SGD:S000003736; VEuPathDB:YJL200C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable 4 iron, 4 sulfur cluster binding activity and aconitate hydratase activity. Involved in tricarboxylic acid cycle. Located in mitochondrion. Human ortholog(s) of this gene implicated in infantile cerebellar-retinal degeneration and optic atrophy 9. Orthologous to human ACO2 (aconitase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ACO2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (56444..58813, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Prp21p Neighboring gene Ecm25p Neighboring gene tRNA-Thr Neighboring gene Mbb1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. 5-Aminolevulinic acid fermentation using engineered Saccharomyces cerevisiae. Hara KY, et al. Microb Cell Fact, 2019 Nov 7. PMID 31699086, Free PMC Article
  2. Minor Isozymes Tailor Yeast Metabolism to Carbon Availability. Bradley PH, et al. mSystems, 2019 Jan-Feb. PMID 30834327, Free PMC Article
  3. Transcriptional profiling shows that Gcn4p is a master regulator of gene expression during amino acid starvation in yeast. Natarajan K, et al. Mol Cell Biol, 2001 Jul. PMID 11390663, Free PMC Article
  4. Transient mRNA responses in chemostat cultures as a method of defining putative regulatory elements: application to genes involved in Saccharomyces cerevisiae acetyl-coenzyme A metabolism. van den Berg MA, et al. Yeast, 1998 Sep 15. PMID 9778795
  5. Adjustment of trehalose metabolism in wine Saccharomyces cerevisiae strains to modify ethanol yields. Rossouw D, et al. Appl Environ Microbiol, 2013 Sep. PMID 23793638, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables aconitate hydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aconitate hydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables aconitate hydratase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lysine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lysine biosynthetic process via aminoadipic acid IEA
Inferred from Electronic Annotation
more info
  
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in tricarboxylic acid cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
aconitate hydratase ACO2
NP_012335.1
  • Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    56444..58813 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181633.1 → NP_012335.1  TPA: aconitate hydratase ACO2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012335.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVZ3, P39533
    UniProtKB/TrEMBL
    A0A8H4C0Q4, C7GUF3, C8ZB20, G2WGH9
    Conserved Domains (1) summary
    TIGR01340
    Location:35 → 782
    aconitase_mito; aconitate hydratase, mitochondrial
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39533.1

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