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RPE1 ribulose-phosphate 3-epimerase RPE1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853322, updated on 13-Apr-2024

Summary

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Gene symbol
RPE1
Gene description
ribulose-phosphate 3-epimerase RPE1
Primary source
SGD:S000003657
Locus tag
YJL121C
See related
AllianceGenome:SGD:S000003657
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
EPI1; POS18
Summary
Enables ribulose-phosphate 3-epimerase activity. Involved in pentose-phosphate shunt. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Orthologous to several human genes including RPE (ribulose-5-phosphate-3-epimerase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See RPE1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (190374..191090, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Mtc1p Neighboring gene Alb1p Neighboring gene uncharacterized protein Neighboring gene Pho86p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Iterative optimization of xylose catabolism in Saccharomyces cerevisiae using combinatorial expression tuning. Latimer LN, et al. Biotechnol Bioeng, 2017 Jun. PMID 28165133
  2. Central carbon metabolism of Saccharomyces cerevisiae explored by biosynthetic fractional (13)C labeling of common amino acids. Maaheimo H, et al. Eur J Biochem, 2001 Apr. PMID 11298766
  3. Cloning and characterization of the first two genes of the non-oxidative part of the Saccharomyces cerevisiae pentose-phosphate pathway. Miosga T, et al. Curr Genet, 1996 Nov. PMID 8929392
  4. Tolerance to furfural-induced stress is associated with pentose phosphate pathway genes ZWF1, GND1, RPE1, and TKL1 in Saccharomyces cerevisiae. Gorsich SW, et al. Appl Microbiol Biotechnol, 2006 Jul. PMID 16222531
  5. Mutants that show increased sensitivity to hydrogen peroxide reveal an important role for the pentose phosphate pathway in protection of yeast against oxidative stress. Juhnke H, et al. Mol Gen Genet, 1996 Sep 25. PMID 8879247

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables D-ribulose-phosphate 3-epimerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables D-ribulose-phosphate 3-epimerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables D-ribulose-phosphate 3-epimerase activity IEA
Inferred from Electronic Annotation
more info
  
enables D-ribulose-phosphate 3-epimerase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pentose-phosphate shunt IEA
Inferred from Electronic Annotation
more info
  
involved_in pentose-phosphate shunt IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pentose-phosphate shunt, non-oxidative branch IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in small molecule metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
ribulose-phosphate 3-epimerase RPE1
NP_012414.1
  • D-ribulose-5-phosphate 3-epimerase; catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    190374..191090 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181554.1 → NP_012414.1  TPA: ribulose-phosphate 3-epimerase RPE1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012414.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VW65, P46969
    UniProtKB/TrEMBL
    A0A6A5PTK5, A6ZQL0, B3LPZ8, C7GQ07, C8ZB98, G2WGQ2, N1P417
    Conserved Domains (1) summary
    PTZ00170
    Location:3 → 234
    PTZ00170; D-ribulose-5-phosphate 3-epimerase; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P46969.1

Gene LinkOut

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