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TES1 palmitoyl-CoA hydrolase [ Saccharomyces cerevisiae S288C ]

Gene ID: 853477, updated on 13-Apr-2024

Summary

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Gene symbol
TES1
Gene description
palmitoyl-CoA hydrolase
Primary source
SGD:S000003780
Locus tag
YJR019C
See related
AllianceGenome:SGD:S000003780
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
PTE1
Summary
Enables acyl-CoA hydrolase activity. Involved in fatty acid beta-oxidation. Located in peroxisome. Orthologous to human ACOT8 (acyl-CoA thioesterase 8). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (467232..468281, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene dihydroxy-acid dehydratase ILV3 Neighboring gene peptidylprolyl isomerase ESS1 Neighboring gene Rec107p Neighboring gene U4/U6-U5 snRNP complex subunit LSM8

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The peroxisomal Acyl-CoA thioesterase Pte1p from Saccharomyces cerevisiae is required for efficient degradation of short straight chain and branched chain fatty acids. Maeda I, et al. J Biol Chem, 2006 Apr 28. PMID 16490786
  2. Oleate beta-oxidation in yeast involves thioesterase but not Yor180c protein that is not a dienoyl-CoA isomerase. Ntamack AG, et al. Biochim Biophys Acta, 2009 May. PMID 19830908, Free PMC Article
  3. Identification of peroxisomal acyl-CoA thioesterases in yeast and humans. Jones JM, et al. J Biol Chem, 1999 Apr 2. PMID 10092594
  4. Yeast transcription factor Oaf1 forms homodimer and induces some oleate-responsive genes in absence of Pip2. Trzcinska-Danielewicz J, et al. Biochem Biophys Res Commun, 2008 Oct 3. PMID 18671944
  5. Metabolic engineering of Saccharomyces cerevisiae for itaconic acid production. Blazeck J, et al. Appl Microbiol Biotechnol, 2014 Oct. PMID 24997118

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables fatty acyl-CoA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fatty acyl-CoA hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables fatty acyl-CoA hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in acyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in acyl-CoA metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid beta-oxidation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fatty acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid oxidation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in peroxisomal matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
palmitoyl-CoA hydrolase
NP_012553.3
  • Peroxisomal acyl-CoA thioesterase; likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    467232..468281 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181677.3 → NP_012553.3  TPA: palmitoyl-CoA hydrolase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012553.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWJ4, P41903
    UniProtKB/TrEMBL
    A0A6A5PXC2, A6ZPY6, C7GWK8, D3UF81, G2WH31, N1P1H8
    Conserved Domains (1) summary
    COG1946
    Location:4 → 344
    TesB; Acyl-CoA thioesterase [Lipid transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P41903.1

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