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OSM1 fumarate reductase [ Saccharomyces cerevisiae S288C ]

Gene ID: 853510, updated on 5-May-2024

Summary

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Gene symbol
OSM1
Gene description
fumarate reductase
Primary source
SGD:S000003812
Locus tag
YJR051W
See related
AllianceGenome:SGD:S000003812
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables fumarate reductase (NADH) activity. Involved in FAD metabolic process and protein folding in endoplasmic reticulum. Located in endoplasmic reticulum and mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (529861..531366)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene NADH/NAD(+) kinase Neighboring gene Isy1p Neighboring gene tRNA-Gly Neighboring gene UV-damaged DNA-binding protein RAD7

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Preparation of stable recombinant Osm1 noncovalently bound with flavin adenosine dinucleotide cofactor for structural study. Kim S, et al. Acta Crystallogr F Struct Biol Commun, 2019 Mar 1. PMID 30839289, Free PMC Article
  2. Physical analysis of the CYC1-sup4 interval in Saccharomyces cerevisiae. Shalit P, et al. Mol Cell Biol, 1981 Mar. PMID 6765599, Free PMC Article
  3. A mutator affecting the region of the iso-1-cytochrome c gene in yeast. Liebman SW, et al. Genetics, 1979 Jul. PMID 231539, Free PMC Article
  4. Deletions of the iso-1-cytochrome c and adjacent genes of yeast: discovery of the OSM1 gene controlling osmotic sensitivity. Singh A, et al. Genetics, 1978 Aug. PMID 211068, Free PMC Article
  5. Targeting and plasticity of mitochondrial proteins revealed by proximity-specific ribosome profiling. Williams CC, et al. Science, 2014 Nov 7. PMID 25378625, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. It has been concluded that soluble eukaryotic fumarate reductases can maintain an oxidizing environment under anaerobic conditions, either by oxidizing cellular flavin cofactors or by a direct interaction with flavoenzymes such as Ero1.
    Title: Molecular basis of maintaining an oxidizing environment under anaerobiosis by soluble fumarate reductase.
  2. Authors show that the fumarate reductase Osm1, which facilitates electron transfer from fumarate to succinate, fills this gap as a new electron acceptor. In addition to microsomes, Osm1 localizes to the mitochondrial intermembrane space and assembles with Erv1 in a complex.
    Title: Osm1 facilitates the transfer of electrons from Erv1 to fumarate in the redox-regulated import pathway in the mitochondrial intermembrane space.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables FMN binding IEA
Inferred from Electronic Annotation
more info
  
enables fumarate reductase (NADH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables fumarate reductase (NADH) activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in FAD metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein folding in endoplasmic reticulum IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
fumarate reductase
NP_012585.1
  • Fumarate reductase, catalyzes the reduction of fumarate to succinate; required for the reoxidation of intracellular NADH under anaerobic conditions; acts as electron acceptor in mitochondrial intermembrane space; has two translation start sites, one at the annotated start codon which produces an ER-targeted form required for anaerobic growth, and one at codon 32 which produces a mitochondrially-targeted form; OSM1 has a paralog, FRD1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    529861..531366
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181709.1 → NP_012585.1  TPA: fumarate reductase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012585.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWM2, P21375
    UniProtKB/TrEMBL
    A0A8H4FAT6, A6ZQ10, B3LQE0, C7GVF5, D3UF98, G2WH56, N1P135
    Conserved Domains (1) summary
    TIGR01813
    Location:36 → 495
    flavo_cyto_c; flavocytochrome c
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P21375.3

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