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XPT1 xanthine phosphoribosyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 853597, updated on 13-Apr-2024

Summary

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Gene symbol
XPT1
Gene description
xanthine phosphoribosyltransferase
Primary source
SGD:S000003894
Locus tag
YJR133W
See related
AllianceGenome:SGD:S000003894
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables hypoxanthine phosphoribosyltransferase activity and xanthine phosphoribosyltransferase activity. Involved in XMP salvage and hypoxanthine metabolic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (672991..673620)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene mannosyl-oligosaccharide 1,2-alpha-mannosidase Neighboring gene Nmd5p Neighboring gene Sgm1p Neighboring gene Mcm22p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation and characterization of the Saccharomyces cerevisiae XPT1 gene encoding xanthine phosphoribosyl transferase. Guetsova ML, et al. J Bacteriol, 1999 May. PMID 10217799, Free PMC Article
  2. Control of ATP homeostasis during the respiro-fermentative transition in yeast. Walther T, et al. Mol Syst Biol, 2010. PMID 20087341, Free PMC Article
  3. Genetic investigation of purine nucleotide imbalance in Saccharomyces cerevisiae. Saint-Marc C, et al. Curr Genet, 2020 Dec. PMID 32780163
  4. Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X. Galibert F, et al. EMBO J, 1996 May 1. PMID 8641269, Free PMC Article
  5. Genome-wide analysis to identify pathways affecting telomere-initiated senescence in budding yeast. Chang HY, et al. G3 (Bethesda), 2011 Aug. PMID 22384331, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables hypoxanthine phosphoribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hypoxanthine phosphoribosyltransferase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables xanthine phosphoribosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in GMP salvage IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in IMP salvage IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in XMP salvage IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in XMP salvage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hypoxanthine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hypoxanthine metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in purine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
xanthine phosphoribosyltransferase
NP_012667.1
  • Xanthine-guanine phosphoribosyl transferase; required for xanthine utilization and for optimal utilization of guanine

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    672991..673620
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181791.1 → NP_012667.1  TPA: xanthine phosphoribosyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012667.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWV1, P47165
    UniProtKB/TrEMBL
    A0A6A5PXM8, A6ZQ88, B3LQL5, C7GM80, C8ZBT1, G2WHD5, N1P1A8
    Conserved Domains (1) summary
    COG2236
    Location:3 → 205
    Hpt1; Hypoxanthine phosphoribosyltransferase [Coenzyme transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47165.1

Gene LinkOut

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