MET5 sulfite reductase (NADPH) subunit beta [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: MET5
Gene description: sulfite reductase (NADPH) subunit beta
Primary source: SGD:S000003898
Locus tag: YJR137C
See related: AllianceGenome:SGD:S000003898
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: ECM17
Summary: Contributes to sulfite reductase (NADPH) activity. Involved in sulfate assimilation and sulfur amino acid biosynthetic process. Located in cell periphery; cytoplasmic stress granule; and fungal-type vacuole. Part of sulfite reductase complex (NADPH). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: X

Exon count:: 1

Sequence:: Chromosome: X; NC_001142.9 (678957..683285, complement)

Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Specific mutations in the MET10 and MET5 genes, which encode the catalytic alpha- and beta-subunits of the sulfite reductase enzyme, respectively, were identified in strains producing decreased amount of H2S.
Title: Isolation of sulfite reductase variants of a commercial wine yeast with significantly reduced hydrogen sulfide production.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables FMN binding	IEA Inferred from Electronic Annotation more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables sulfite reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info
enables sulfite reductase (ferredoxin) activity	IBA Inferred from Biological aspect of Ancestor more info
enables sulfite reductase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in hydrogen sulfide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in sulfate assimilation	IBA Inferred from Biological aspect of Ancestor more info
involved_in sulfate assimilation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sulfur amino acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell periphery	HDA more info	PubMed
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic stress granule	HDA more info	PubMed
located_in fungal-type vacuole	HDA more info	PubMed
part_of sulfite reductase complex (NADPH)	IBA Inferred from Biological aspect of Ancestor more info
part_of sulfite reductase complex (NADPH)	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: sulfite reductase (NADPH) subunit beta

NP_116579.1

EC 1.8.1.2

Sulfite reductase beta subunit; involved in amino acid biosynthesis, transcription repressed by methionine

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001142.9 Reference assembly

Range

678957..683285 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181795.1 → NP_116579.1 TPA: sulfite reductase (NADPH) subunit beta [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_116579.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VWV6, P47169

UniProtKB/TrEMBL

A0A023VU52, C7GM75, E9P9D7, E9P9D8, E9P9D9, E9P9E0, E9P9H6, N1P0B3

Conserved Domains (4) summary

COG0674
Location:10 → 345

PorA; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, alpha subunit [Energy production and conversion]

PRK13504
Location:843 → 1434

PRK13504; NADPH-dependent assimilatory sulfite reductase hemoprotein subunit

pfam00258
Location:684 → 826

Flavodoxin_1

cl01629
Location:347 → 664

TPP_enzymes; Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and ...