PRS1 ribose phosphate diphosphokinase subunit PRS1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: PRS1
Gene description: ribose phosphate diphosphokinase subunit PRS1
Primary source: SGD:S000001664
Locus tag: YKL181W
See related: AllianceGenome:SGD:S000001664
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: PRP1
Summary: Contributes to ribose phosphate diphosphokinase activity. Involved in 5-phosphoribose 1-diphosphate biosynthetic process and fungal-type cell wall organization. Located in cytoplasm. Part of ribose phosphate diphosphokinase complex. Used to study Arts syndrome; Charcot-Marie-Tooth disease X-linked recessive 5; and X-linked nonsyndromic deafness. Orthologous to human PRPSAP1 (phosphoribosyl pyrophosphate synthetase associated protein 1) and PRPSAP2 (phosphoribosyl pyrophosphate synthetase associated protein 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: XI

Exon count:: 1

Sequence:: Chromosome: XI; NC_001143.9 (107316..108599)

Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deletion of 284KKCPK288 pentameric motif from Prs3 destabilises the Prs1/Prs3 complex resulting in a cascade of events, including reduction in phosphoribosyl pyrophosphate synthetase activity and altered cell wall integrity (CWI) as measured by caffeine sensitivity and Rlm1 expression.
Title: The NHR1-1 of Prs1 and the pentameric motif 284KKCPK288 of Prs3 permit multi-functionality of the PRPP synthetase in Saccharomyces cerevisiae.
In addition to interacting with Prs3, Prs1 also interacts with Slt2, the MAPK of the cell wall integrity (CWI) pathway.
Title: The contribution of the nonhomologous region of Prs1 to the maintenance of cell wall integrity and cell viability.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ribose phosphate diphosphokinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 5-phosphoribose 1-diphosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in 5-phosphoribose 1-diphosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in 5-phosphoribose 1-diphosphate biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in 5-phosphoribose 1-diphosphate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fungal-type cell wall organization	IEA Inferred from Electronic Annotation more info
involved_in nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in purine nucleotide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribonucleoside monophosphate biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic stress granule	HDA more info	PubMed
part_of ribose phosphate diphosphokinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ribose phosphate diphosphokinase complex	IDA Inferred from Direct Assay more info	PubMed
part_of ribose phosphate diphosphokinase complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ribose phosphate diphosphokinase subunit PRS1

NP_012740.1

EC 2.7.6.1

5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; plays a key role in cell wall integrity (CWI) pathway; one of five related enzymes, which are active as heteromultimeric complexes; missense mutations in human homolog PRPS1 are associated with neuropathic Arts syndrome and Charcot-Marie Tooth (CMTX5) disease

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001143.9 Reference assembly

Range

107316..108599

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179747.1 → NP_012740.1 TPA: ribose phosphate diphosphokinase subunit PRS1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012740.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VX20, P32895

UniProtKB/TrEMBL

A0A6A5PUV7, A6ZZE5, B3LQS5, B5VLY4, C7GJ29, C8ZBZ4, G2WHL2, N1NZM5

Conserved Domains (1) summary

COG0462
Location:1 → 422

PrsA; Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism, Amino acid transport and metabolism]