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JEN1 monocarboxylate/H+ symporter [ Saccharomyces cerevisiae S288C ]

Gene ID: 853663, updated on 11-Apr-2024

Summary

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Gene symbol
JEN1
Gene description
monocarboxylate/H+ symporter
Primary source
SGD:S000001700
Locus tag
YKL217W
See related
AllianceGenome:SGD:S000001700
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables secondary active monocarboxylate transmembrane transporter activity and selenite:proton symporter activity. Involved in plasma membrane lactate transport; plasma membrane pyruvate transport; and plasma membrane selenite transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (22234..24084)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Cos9p Neighboring gene threo-3-hydroxy-L-aspartate ammonia-lyase SRY1 Neighboring gene dihydroorotate dehydrogenase Neighboring gene 5-oxoprolinase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Improvement of ethanol production from D-lactic acid by constitutive expression of lactate transporter Jen1p in Saccharomyces cerevisiae. Wakamatsu M, et al. Biosci Biotechnol Biochem, 2013. PMID 23649240
  2. A substrate translocation trajectory in a cytoplasm-facing topological model of the monocarboxylate/H⁺ symporter Jen1p. Soares-Silva I, et al. Mol Microbiol, 2011 Aug. PMID 21651629
  3. Jen1p: a high affinity selenite transporter in yeast. McDermott JR, et al. Mol Biol Cell, 2010 Nov 15. PMID 20861301, Free PMC Article
  4. The conserved sequence NXX[S/T]HX[S/T]QDXXXT of the lactate/pyruvate:H(+) symporter subfamily defines the function of the substrate translocation pathway. Soares-Silva I, et al. Mol Membr Biol, 2007 Sep-Dec. PMID 17710650
  5. Multiple transcripts regulate glucose-triggered mRNA decay of the lactate transporter JEN1 from Saccharomyces cerevisiae. Andrade RP, et al. Biochem Biophys Res Commun, 2005 Jun 24. PMID 15896325

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Saccharomyces cerevisiae can use two transport mechanisms to import lactic acid: a 'saturable' component of the transport, which requires the presence of a functional Jen1p transporter, and a Jen1p independent 'non-saturable' component.
    Title: The transport of carboxylic acids and important role of the Jen1p transporter during the development of yeast colonies.
  2. study demonstrated that monocarboxylate transporters Jen1 and Ady2 are modulators of lactic acid production
    Title: Lactic acid production in Saccharomyces cerevisiae is modulated by expression of the monocarboxylate transporters Jen1 and Ady2.
  3. Data show that overexpression of Jen1p enables selenite accumulation in yeast compared with a JEN1 knock out strain.
    Title: Jen1p: a high affinity selenite transporter in yeast.
  4. Data show that casein kinase 1-dependent phosphorylation and HECT-ubiquitin ligase Rsp5-dependent ubiquitylation are required for Jen1 endocytosis.
    Title: Glucose-induced ubiquitylation and endocytosis of the yeast Jen1 transporter: role of lysine 63-linked ubiquitin chains.
  5. The presence of the JEN1(+391) transcript correlated with rapid glucose-triggered mRNA degradation of the JEN1(-51) transcript, whereas when the small transcript started at position +972, the JEN1(-51) mRNA turnover rate was unaffected.
    Title: Multiple transcripts regulate glucose-triggered mRNA decay of the lactate transporter JEN1 from Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables organic anion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables secondary active monocarboxylate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables secondary active monocarboxylate transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables selenite:proton symporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables sialic acid transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in plasma membrane lactate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in plasma membrane lactate transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in plasma membrane pyruvate transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in plasma membrane selenite transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sialic acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in fungal-type vacuole HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
monocarboxylate/H+ symporter
NP_012705.1
  • Monocarboxylate/proton symporter of the plasma membrane; transport activity is dependent on the pH gradient across the membrane; mediates high-affinity uptake of carbon sources lactate, pyuvate, and acetate, and also of the micronutrient selenite, whose structure mimics that of monocarboxylates; expression and localization are tightly regulated, with transcription repression, mRNA degradation, and protein endocytosis and degradation all occurring in the presence of glucose

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    22234..24084
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179782.1 → NP_012705.1  TPA: monocarboxylate/H+ symporter [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012705.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWY6, P36035
    UniProtKB/TrEMBL
    A0A8H4C038, B3LQP2, B5VLU8, C7GIZ6, G2WHH7, N1P0Q3
    Conserved Domains (1) summary
    TIGR00891
    Location:129 → 544
    2A0112; putative sialic acid transporter
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36035.1

Gene LinkOut

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