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TRP3 bifunctional anthranilate synthase/indole-3-glycerol-phosphate synthase [ Saccharomyces cerevisiae S288C ]

Gene ID: 853669, updated on 2-May-2024

Summary

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Gene symbol
TRP3
Gene description
bifunctional anthranilate synthase/indole-3-glycerol-phosphate synthase
Primary source
SGD:S000001694
Locus tag
YKL211C
See related
AllianceGenome:SGD:S000001694
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables indole-3-glycerol-phosphate synthase activity. Contributes to anthranilate synthase activity. Involved in tryptophan biosynthetic process. Located in cytoplasm. Part of anthranilate synthase complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (36699..38153, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Doa1p Neighboring gene phosphatidylinositol-3-phosphatase SAC1 Neighboring gene ncRNA Neighboring gene E1 ubiquitin-activating protein UBA1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An allosteric pathway explains beneficial fitness in yeast for long-range mutations in an essential TIM barrel enzyme. Chan YH, et al. Protein Sci, 2020 Sep. PMID 32643222, Free PMC Article
  2. Correlation of fitness landscapes from three orthologous TIM barrels originates from sequence and structure constraints. Chan YH, et al. Nat Commun, 2017 Mar 6. PMID 28262665, Free PMC Article
  3. Structure and function of the TRP3 gene of Saccharomyces cerevisiae: Analysis of 3'- and 5'-deletions in vivo and in vitro. Aebi M, et al. Curr Genet, 1984 Apr. PMID 24177736
  4. Structure and function of the TRP3 gene of Saccharomyces cerevisiae: Analysis of transcription, promoter sequence, and sequence coding for a glutamine amidotransferase. Aebi M, et al. Curr Genet, 1984 Apr. PMID 24177735
  5. The folding of the bifunctional TRP3 protein in yeast is influenced by a translational pause which lies in a region of structural divergence with Escherichia coli indoleglycerol-phosphate synthase. Crombie T, et al. Eur J Biochem, 1994 Dec 1. PMID 8001582

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to anthranilate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables anthranilate synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables indole-3-glycerol-phosphate synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables indole-3-glycerol-phosphate synthase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables indole-3-glycerol-phosphate synthase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in aromatic amino acid family biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glutamine metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in tryptophan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tryptophan biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in tryptophan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tryptophan metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of anthranilate synthase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm HDA PubMed 

General protein information

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Preferred Names
bifunctional anthranilate synthase/indole-3-glycerol-phosphate synthase
NP_012711.1
  • Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    36699..38153 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179776.1 → NP_012711.1  TPA: bifunctional anthranilate synthase/indole-3-glycerol-phosphate synthase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012711.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWZ2, P00937
    UniProtKB/TrEMBL
    A0A6A5PS14, A7A078, B3LQP8, B5VLV6, C7GJ02, C8ZBW9, G2WHI3, N1P7S9
    Conserved Domains (2) summary
    COG0512
    Location:11 → 199
    PabA; Anthranilate/para-aminobenzoate synthase component II [Amino acid transport and metabolism, Coenzyme transport and metabolism]
    pfam00218
    Location:217 → 481
    IGPS; Indole-3-glycerol phosphate synthase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P00937.2

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