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GPM1 phosphoglycerate mutase GPM1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853705, updated on 13-Apr-2024

Summary

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Gene symbol
GPM1
Gene description
phosphoglycerate mutase GPM1
Primary source
SGD:S000001635
Locus tag
YKL152C
See related
AllianceGenome:SGD:S000001635
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables phosphoglycerate mutase activity. Involved in gluconeogenesis and glycolytic process. Located in cytosol and mitochondrial intermembrane space. Human ortholog(s) of this gene implicated in familial erythrocytosis 8 and myoglobinuria. Orthologous to several human genes including BPGM (bisphosphoglycerate mutase); PGAM1 (phosphoglycerate mutase 1); and PGAM2 (phosphoglycerate mutase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (163642..164385, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Signal recognition particle receptor subunit beta Neighboring gene tRNA-Arg Neighboring gene NADHX dehydratase Neighboring gene cytochrome-b5 reductase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phosphoglycerate mutase knock-out mutant Saccharomyces cerevisiae: physiological investigation and transcriptome analysis. Papini M, et al. Biotechnol J, 2010 Oct. PMID 20815084
  2. The kinetic properties of yeast and muscle phosphoglyceric acid mutase. RODWELL VW, et al. J Biol Chem, 1957 Oct. PMID 13475367
  3. The 2.3 A X-ray crystal structure of S. cerevisiae phosphoglycerate mutase. Rigden DJ, et al. J Mol Biol, 1998 Feb 20. PMID 9512715
  4. Transcriptional control of yeast phosphoglycerate mutase-encoding gene. Rodicio R, et al. Gene, 1993 Mar 30. PMID 8462867
  5. Dissociation of the tetrameric phosphoglycerate mutase from yeast by a mutation in the subunit contact region. White MF, et al. Biochem J, 1993 Nov 1. PMID 8240286, Free PMC Article

See all (114) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. at this locus, the intergenic region serves as a focal point of regulatory input, driving antisense expression and mediating the coordinated regulation of YKL151C and GPM1 Together, our findings implicate transcription factors in the joint control of neighboring genes specialized to opposing conditions and the antisense transcripts expressed between them.
    Title: The Role of Transcription Factors at Antisense-Expressing Gene Pairs in Yeast.
  2. Findings strongly suggest a severely impaired growth ability of the GPM1 knock-out mutant, which presents increased transcript levels of genes involved in the pentose phosphate pathway and in the glyoxylate shunt.
    Title: Phosphoglycerate mutase knock-out mutant Saccharomyces cerevisiae: physiological investigation and transcriptome analysis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity IEA
Inferred from Electronic Annotation
more info
  
enables intramolecular phosphotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoglycerate mutase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoglycerate mutase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoglycerate mutase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycolytic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphoglycerate mutase GPM1
NP_012770.1
  • Tetrameric phosphoglycerate mutase; mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    163642..164385 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179718.1 → NP_012770.1  TPA: phosphoglycerate mutase GPM1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012770.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VX45, P00950, Q02117
    UniProtKB/TrEMBL
    A0A6A5PSG4, A6ZZH0, B3LQU9, B5VM12, C7GU53, C8ZC23, G2WHN7, N1P8B2
    Conserved Domains (1) summary
    TIGR01258
    Location:2 → 246
    pgm_1; phosphoglycerate mutase, BPG-dependent, family 1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P00950.3

Gene LinkOut

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