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MCR1 cytochrome-b5 reductase [ Saccharomyces cerevisiae S288C ]

Gene ID: 853707, updated on 13-Apr-2024

Summary

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Gene symbol
MCR1
Gene description
cytochrome-b5 reductase
Primary source
SGD:S000001633
Locus tag
YKL150W
See related
AllianceGenome:SGD:S000001633
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables cytochrome-b5 reductase activity, acting on NAD(P)H. Involved in cellular response to oxidative stress and ergosterol biosynthetic process. Located in mitochondrial intermembrane space and mitochondrial outer membrane. Is integral component of mitochondrial outer membrane. Orthologous to human CYB5R1 (cytochrome b5 reductase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (166544..167452)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene phosphoglycerate mutase GPM1 Neighboring gene NADHX dehydratase Neighboring gene RNA lariat debranching enzyme Neighboring gene succinate dehydrogenase flavoprotein subunit SDH1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Widespread distribution of mcr-1-bearing bacteria in the ecosystem, 2015 to 2016. Chen K, et al. Euro Surveill, 2017 Sep. PMID 29019312, Free PMC Article
  2. Mitochondrial NADH-cytochrome b(5) reductase plays a crucial role in the reduction of D-erythroascorbyl free radical in Saccharomyces cerevisiae. Lee JS, et al. Biochim Biophys Acta, 2001 Jul 2. PMID 11420140
  3. Analysis of the sorting signals directing NADH-cytochrome b5 reductase to two locations within yeast mitochondria. Haucke V, et al. Mol Cell Biol, 1997 Jul. PMID 9199337, Free PMC Article
  4. Incomplete arrest in the outer membrane sorts NADH-cytochrome b5 reductase to two different submitochondrial compartments. Hahne K, et al. Cell, 1994 Dec 2. PMID 8001120
  5. Re-assessment of YAP1 and MCR1 contributions to inhibitor tolerance in robust engineered Saccharomyces cerevisiae fermenting undetoxified lignocellulosic hydrolysate. Wallace-Salinas V, et al. AMB Express, 2014. PMID 25147754, Free PMC Article

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables cytochrome-b5 reductase activity, acting on NAD(P)H IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytochrome-b5 reductase activity, acting on NAD(P)H IDA
Inferred from Direct Assay
more info
 PubMed 
enables cytochrome-b5 reductase activity, acting on NAD(P)H IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ergosterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ergosterol biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane HDA PubMed 
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytochrome-b5 reductase
NP_012772.1
  • Mitochondrial NADH-cytochrome b5 reductase; involved in ergosterol biosynthesis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    166544..167452
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179716.1 → NP_012772.1  TPA: cytochrome-b5 reductase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012772.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A2TBM9, A6ZZH2, D6VX47, P36060
    UniProtKB/TrEMBL
    A0A8H4BXR5, B3LQV1, B5VM14, C7GSN4, C8ZC25, G2WHN9, N1P2Y2
    Conserved Domains (1) summary
    cd06183
    Location:56 → 302
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36060.1

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