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AVT3 Avt3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853710, updated on 25-Apr-2024

Summary

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Gene symbol
AVT3
Gene description
Avt3p
Primary source
SGD:S000001629
Locus tag
YKL146W
See related
AllianceGenome:SGD:S000001629
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables L-glutamine transmembrane transporter activity; L-isoleucine transmembrane transporter activity; and L-tyrosine transmembrane transporter activity. Involved in amino acid transmembrane export from vacuole and proline transport. Located in fungal-type vacuole membrane. Human ortholog(s) of this gene implicated in iminoglycinuria. Orthologous to several human genes including SLC36A1 (solute carrier family 36 member 1) and SLC36A4 (solute carrier family 36 member 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (171783..173861)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene RNA lariat debranching enzyme Neighboring gene succinate dehydrogenase flavoprotein subunit SDH1 Neighboring gene proteasome regulatory particle base subunit RPT1 Neighboring gene DNA-directed RNA polymerase III subunit RPC25

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Vacuolar transporter Avt4 is involved in excretion of basic amino acids from the vacuoles of Saccharomyces cerevisiae. Sekito T, et al. Biosci Biotechnol Biochem, 2014. PMID 25036121
  2. Characterization of Avt1p as a vacuolar proton/amino acid antiporter in Saccharomyces cerevisiae. Tone J, et al. Biosci Biotechnol Biochem, 2015. PMID 25747199
  3. Genome-wide screening to study breeding methods to improve the nitrogen accumulation ability of yeast without gene recombinant techniques. Watanabe T, et al. Biosci Biotechnol Biochem, 2013. PMID 23649250
  4. A vacuolar membrane protein Avt7p is involved in transport of amino acid and spore formation in Saccharomyces cerevisiae. Tone J, et al. Biosci Biotechnol Biochem, 2015. PMID 25266154
  5. Vacuolar amino acid transporters upregulated by exogenous proline and involved in cellular localization of proline in Saccharomyces cerevisiae. Nishida I, et al. J Gen Appl Microbiol, 2016 Jul 14. PMID 27246536

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables L-glutamine transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables L-glutamine transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables L-isoleucine transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables L-isoleucine transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables L-tyrosine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-tyrosine transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables L-tyrosine transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-alpha-amino acid transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in amino acid transmembrane export from vacuole IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in amino acid transmembrane export from vacuole IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in branched-chain amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in glutamine transport IEA
Inferred from Electronic Annotation
more info
  
involved_in organic cation transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proline transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tyrosine transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in fungal-type vacuole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in fungal-type vacuole membrane HDA PubMed 
located_in fungal-type vacuole membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in vacuolar membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Avt3p
NP_012776.1
  • Vacuolar transporter; exports large neutral amino acids from vacuole; targeted to vacuole via AP-3 pathway; member of family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    171783..173861
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179712.1 → NP_012776.1  TPA: Avt3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012776.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VX50, P36062
    UniProtKB/TrEMBL
    A0A8H4C079, A6ZZH5, C7GSN7, N1P8B6
    Conserved Domains (1) summary
    pfam01490
    Location:295 → 687
    Aa_trans; Transmembrane amino acid transporter protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36062.1

Gene LinkOut

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