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OAC1 Oac1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853739, updated on 11-Apr-2024

Summary

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Gene symbol
OAC1
Gene description
Oac1p
Primary source
SGD:S000001603
Locus tag
YKL120W
See related
AllianceGenome:SGD:S000001603
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables dicarboxylic acid transmembrane transporter activity and sulfate transmembrane transporter activity. Involved in isopropylmalate transport; oxaloacetate transport; and sulfate transport. Located in mitochondrial inner membrane. Orthologous to several human genes including SLC25A35 (solute carrier family 25 member 35). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See OAC1 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (217344..218318)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene signal recognition particle subunit SRP21 Neighboring gene Dgr2p Neighboring gene Vph2p Neighboring gene tRNA-Ala

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. alpha-Isopropylmalate, a leucine biosynthesis intermediate in yeast, is transported by the mitochondrial oxalacetate carrier. Marobbio CM, et al. J Biol Chem, 2008 Oct 17. PMID 18682385, Free PMC Article
  2. Identification of the yeast mitochondrial transporter for oxaloacetate and sulfate. Palmieri L, et al. J Biol Chem, 1999 Aug 6. PMID 10428783
  3. A critical tyrosine residue determines the uncoupling protein-like activity of the yeast mitochondrial oxaloacetate carrier. Luévano-Martínez LA, et al. Biochem J, 2012 Apr 1. PMID 22236206
  4. Mitochondrial Compartmentalization Confers Specificity to the 2-Ketoacid Recursive Pathway: Increasing Isopentanol Production in Saccharomyces cerevisiae. Hammer SK, et al. ACS Synth Biol, 2020 Mar 20. PMID 32049515
  5. Iterative algorithm-guided design of massive strain libraries, applied to itaconic acid production in yeast. Young EM, et al. Metab Eng, 2018 Jul. PMID 29753070

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables isopropylmalate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables malonate(1-) transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxaloacetate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sulfate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in isopropylmalate transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in malonic acid transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in oxaloacetate transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in oxaloacetate(2-) transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sulfate transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sulfate transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Oac1p
NP_012802.1
  • Mitochondrial inner membrane transporter; transports oxaloacetate, sulfate, thiosulfate, and isopropylmalate; member of the mitochondrial carrier family

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    217344..218318
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179686.1 → NP_012802.1  TPA: Oac1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012802.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXH0, P32332
    UniProtKB/TrEMBL
    A0A6A5PRT4, A6ZZJ9, B3LQX8, B5VM41, C7GVJ4, C8ZC55, G2WHR6, N1P308
    Conserved Domains (1) summary
    PTZ00169
    Location:26 → 294
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32332.1

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