OAR1 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: OAR1
Gene description: 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH)
Primary source: SGD:S000001538
Locus tag: YKL055C
See related: AllianceGenome:SGD:S000001538
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity. Involved in aerobic respiration and fatty acid metabolic process. Located in mitochondrion. Used to study mitochondrial metabolism disease. Orthologous to human CBR4 (carbonyl reductase 4) and HSD17B8 (hydroxysteroid 17-beta dehydrogenase 8). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See OAR1 in Genome Data Viewer

Location:: chromosome: XI

Exon count:: 1

Sequence:: Chromosome: XI; NC_001143.9 (335321..336157, complement)

Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ymtOAR1 forms a homodimer, and undergoes conformational changes upon NADPH binding to the active site.
Title: Structural insights into cofactor recognition of yeast mitochondria 3-oxoacyl-ACP reductase OAR1.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	IDA Inferred from Direct Assay more info	PubMed
enables 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info
enables 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IBA Inferred from Biological aspect of Ancestor more info
enables quinone binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in aerobic respiration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH)

NP_012868.1

EC 1.1.1.100

Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase; may comprise a type II mitochondrial fatty acid synthase along with Mct1p; human homolog CBR4 complements yeast null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001143.9 Reference assembly

Range

335321..336157 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179621.2 → NP_012868.1 TPA: 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012868.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VXN2, P35731

UniProtKB/TrEMBL

A0A8H4BXY0, B3LR36, B5VMA1, C7GP19, C8ZCB7, N1P0M1

Conserved Domains (1) summary

cd05233
Location:7 → 275

SDR_c; classical (c) SDRs