AUR1 inositol phosphorylceramide synthase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: AUR1
Gene description: inositol phosphorylceramide synthase
Primary source: SGD:S000001487
Locus tag: YKL004W
See related: AllianceGenome:SGD:S000001487
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables inositol phosphoceramide synthase activity. Involved in inositol phosphoceramide metabolic process and sphingolipid biosynthetic process. Located in Golgi apparatus. Part of inositol phosphoceramide synthase complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: XI

Exon count:: 1

Sequence:: Chromosome: XI; NC_001143.9 (435580..436785)

Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Crosstalk between protein kinase A and the HOG pathway under impaired biosynthesis of complex sphingolipids in budding yeast.
Title: Crosstalk between protein kinase A and the HOG pathway under impaired biosynthesis of complex sphingolipids in budding yeast.
Deletion of AUR1 allows cell growth, but leads to a defect in cytokinesis, which takes twice as long as in wild-type strains.
Title: An essential function of sphingolipids in yeast cell division.
it is suggested that the deletion of sphingolipid hydroxylases changes the toxicity of ceramide under AUR1-repressive conditions.
Title: Hydroxylation state of fatty acid and long-chain base moieties of sphingolipid determine the sensitivity to growth inhibition due to AUR1 repression in Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables inositol phosphoceramide synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables inositol phosphoceramide synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables inositol phosphoceramide synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in inositol phosphoceramide metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in inositol phosphoceramide metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in sphingolipid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in sphingolipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sphingolipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi cisterna membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	HDA more info	PubMed
part_of inositol phosphoceramide synthase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of inositol phosphoceramide synthase complex	IPI Inferred from Physical Interaction more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: inositol phosphorylceramide synthase

NP_012922.1

EC 2.7.1.227

Phosphatidylinositol:ceramide phosphoinositol transferase; required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance; also known as IPC synthase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001143.9 Reference assembly

Range

435580..436785

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179570.1 → NP_012922.1 TPA: inositol phosphorylceramide synthase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012922.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VXT3, P36107, Q92324

UniProtKB/TrEMBL

A0A6A5PVZ0, A6ZZW2, B3LR81, B5VME8, C7GQH1, C8ZCG3, N1P0U4

Conserved Domains (1) summary

cd03386
Location:122 → 317

PAP2_Aur1_like; PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin.