U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PTR2 Ptr2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853968, updated on 5-May-2024

Summary

Go to the top of the page Help
Gene symbol
PTR2
Gene description
Ptr2p
Primary source
SGD:S000001801
Locus tag
YKR093W
See related
AllianceGenome:SGD:S000001801
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables dipeptide transmembrane transporter activity and tripeptide transmembrane transporter activity. Involved in dipeptide transport and tripeptide transport. Located in plasma membrane. Orthologous to several human genes including SLC15A3 (solute carrier family 15 member 3) and SLC15A4 (solute carrier family 15 member 4). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (615730..617535)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene DNA-binding protein SRL3 Neighboring gene Srp40p Neighboring gene ubiquitin-ribosomal 60S subunit protein L40B fusion protein Neighboring gene Mlp1p

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The benefits and risks of expressing the POT and FOT family of oligopeptide transporters in Saccharomyces cerevisiae. Kitamura K, et al. Biosci Biotechnol Biochem, 2018 Mar. PMID 29447073
  2. Critical role of the proton-dependent oligopeptide transporter (POT) in the cellular uptake of the peptidyl nucleoside antibiotic, blasticidin S. Kitamura K, et al. Biochim Biophys Acta Mol Cell Res, 2017 Feb. PMID 27916534
  3. New mechanisms that regulate Saccharomyces cerevisiae short peptide transporter achieve balanced intracellular amino acid concentrations. Melnykov AV. Yeast, 2016 Jan. PMID 26537311
  4. Expression profiling and functional analyses of BghPTR2, a peptide transporter from Blumeria graminis f. sp. hordei. Droce A, et al. Fungal Biol, 2015 Jul. PMID 26058531
  5. Analysing the substrate multispecificity of a proton-coupled oligopeptide transporter using a dipeptide library. Ito K, et al. Nat Commun, 2013. PMID 24060756, Free PMC Article

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. some mutants of Ptr2 that are dysfunctional in dipeptide uptake were still competent to transport BlaS. Mouse-derived oligopeptide transporter PepT1 conferred BlaS sensitivity in the S. cerevisiae ptr2 mutant
    Title: Critical role of the proton-dependent oligopeptide transporter (POT) in the cellular uptake of the peptidyl nucleoside antibiotic, blasticidin S.
  2. Ptr2 mutants of the peptide-binding site exhibited severe defects in peptide import and were subject to Rsp5-dependent degradation suggesting that Ptr2 undergoes quality control that renders Ptr2 subject to efficient ubiquitination and degradation.
    Title: Functional implications and ubiquitin-dependent degradation of the peptide transporter Ptr2 in Saccharomyces cerevisiae.
  3. The substrate multispecificity of PTR2 indicates that it has an important role in the preferential uptake of vital amino acids.
    Title: Analysing the substrate multispecificity of a proton-coupled oligopeptide transporter using a dipeptide library.
  4. These studies highlight the complementary activities of two dipeptide transport systems under different regulatory controls in common laboratory yeast strains.
    Title: Differential regulation and substrate preferences in two peptide transporters of Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables dipeptide transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dipeptide transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptide transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables tripeptide transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tripeptide transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in dipeptide import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dipeptide transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in oligopeptide transport IEA
Inferred from Electronic Annotation
more info
  
involved_in peptide transport IEA
Inferred from Electronic Annotation
more info
  
involved_in peptide transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in tripeptide transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in fungal-type vacuole HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
Ptr2p
NP_013019.1
  • Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by N-end rule pathway via repression by Cup9p; targeted to vacuole via AP-3 pathway

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    615730..617535
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179883.1 → NP_013019.1  TPA: Ptr2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013019.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXF3, P32901
    UniProtKB/TrEMBL
    A0A8H4C0N8, A7A052, N1P107
    Conserved Domains (1) summary
    cd17350
    Location:79 → 554
    MFS_PTR2; Peptide transporter PTR2 of the Major Facilitator Superfamily of transporters
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32901.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous