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ARG8 acetylornithine transaminase [ Saccharomyces cerevisiae S288C ]

Gene ID: 854025, updated on 17-May-2024

Summary

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Gene symbol
ARG8
Gene description
acetylornithine transaminase
Primary source
FungiDB:YOL140W
Locus tag
YOL140W
See related
SGD:S000005500; AllianceGenome:SGD:S000005500
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity. Predicted to be involved in arginine biosynthetic process and ornithine biosynthetic process. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ARG8 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (58759..60030)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene exosome non-catalytic core subunit RRP40 Neighboring gene tRNA methyltransferase PPM2 Neighboring gene translation initiation factor eIF4E Neighboring gene Rtc1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Further definition of the sequence and position requirements of the arginine control element that mediates repression and induction by arginine in Saccharomyces cerevisiae. Crabeel M, et al. Yeast, 1995 Nov. PMID 8585320
  2. An antioxidative mechanism mediated by the yeast N-acetyltransferase Mpr1: oxidative stress-induced arginine synthesis and its physiological role. Nishimura A, et al. FEMS Yeast Res, 2010 Sep. PMID 20550582
  3. The N-acetylglutamate synthase/N-acetylglutamate kinase metabolon of Saccharomyces cerevisiae allows co-ordinated feedback regulation of the first two steps in arginine biosynthesis. Pauwels K, et al. Eur J Biochem, 2003 Mar. PMID 12603335
  4. Expression of a recoded nuclear gene inserted into yeast mitochondrial DNA is limited by mRNA-specific translational activation. Steele DF, et al. Proc Natl Acad Sci U S A, 1996 May 28. PMID 8643562, Free PMC Article
  5. Inositol polyphosphate multikinase is a nuclear PI3-kinase with transcriptional regulatory activity. Resnick AC, et al. Proc Natl Acad Sci U S A, 2005 Sep 6. PMID 16123124, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyridoxal phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables transaminase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in arginine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in arginine biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in arginine metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ornithine biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
acetylornithine transaminase
NP_014501.1
  • Acetylornithine aminotransferase; catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    58759..60030
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183394.1 → NP_014501.1  TPA: acetylornithine transaminase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014501.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1S9, P18544
    UniProtKB/TrEMBL
    A0A8H4F8F4, A6ZN72, B3LIS7, B5VRC1, C7GV15, C8ZHH7, G2WM98, N1NYC6
    Conserved Domains (1) summary
    TIGR00707
    Location:23 → 418
    argD; transaminase, acetylornithine/succinylornithine family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P18544.1

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