COQ3 hexaprenyldihydroxybenzoate methyltransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: COQ3
Gene description: hexaprenyldihydroxybenzoate methyltransferase
Primary source: FungiDB:YOL096C
Locus tag: YOL096C
See related: SGD:S000005456; AllianceGenome:SGD:S000005456
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables 3-demethylubiquinol-6 3-O-methyltransferase activity and hexaprenyldihydroxybenzoate methyltransferase activity. Involved in ubiquinone biosynthetic process. Located in mitochondrial inner membrane. Is extrinsic component of membrane. Orthologous to human COQ3 (coenzyme Q3, methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (138107..139045, complement)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Coq3p relevant residues for protein activity and stability.
Title: Coq3p relevant residues for protein activity and stability.
putative candidate for phosphorylation by Coq8p.
Title: Ubiquinone biosynthesis in Saccharomyces cerevisiae: the molecular organization of O-methylase Coq3p depends on Abc1p/Coq8p.
study identifies Coq3 peptide and Coq4 peptide as defining members of a Q-biosynthetic Coq polypeptide complex
Title: Coq3 and Coq4 define a polypeptide complex in yeast mitochondria for the biosynthesis of coenzyme Q.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables 3-demethylubiquinol-n 3-O-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables 3-demethylubiquinol-n 3-O-methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in ubiquinone biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquinone biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in ubiquinone biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in ubiquinone biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extrinsic component of mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: hexaprenyldihydroxybenzoate methyltransferase

NP_014545.2

EC 2.1.1.114

EC 2.1.1.64

O-methyltransferase; catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

138107..139045 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183350.1 → NP_014545.2 TPA: hexaprenyldihydroxybenzoate methyltransferase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014545.2

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W1X2, P27680

UniProtKB/TrEMBL

A0A8H4BWK6, A6ZNB4, G2WMD9, N1NWB9

Conserved Domains (1) summary

TIGR01983
Location:40 → 305

UbiG; ubiquinone biosynthesis O-methyltransferase