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PLB3 lysophospholipase [ Saccharomyces cerevisiae S288C ]

Gene ID: 854151, updated on 13-Apr-2024

Summary

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Gene symbol
PLB3
Gene description
lysophospholipase
Primary source
SGD:S000005371
Locus tag
YOL011W
See related
AllianceGenome:SGD:S000005371
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables lysophospholipase activity. Involved in phosphatidylinositol metabolic process and phosphatidylserine catabolic process. Located in extracellular region. Orthologous to several human genes including JMJD7-PLA2G4B (JMJD7-PLA2G4B readthrough); PLA2G4A (phospholipase A2 group IVA); and PLA2G4D (phospholipase A2 group IVD). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (305349..307409)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene E3 ubiquitin-protein ligase HRD1 Neighboring gene histone H2AZ Neighboring gene rRNA-processing endoribonuclease Neighboring gene ERMES complex subunit MDM12

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Lysophospholipids Facilitate COPII Vesicle Formation. Melero A, et al. Curr Biol, 2018 Jun 18. PMID 29887313, Free PMC Article
  2. Development and validation of a hydrophilic interaction liquid chromatography-tandem mass spectrometry method for the quantification of lipid-related extracellular metabolites in Saccharomyces cerevisiae. Sun T, et al. J Chromatogr B Analyt Technol Biomed Life Sci, 2012 May 15. PMID 22541168
  3. Ectopic expression of Arabidopsis phospholipase A genes elucidates role of phospholipase Bs in S. cerevisiae cells. Zhang M, et al. Open Microbiol J, 2009 Aug 13. PMID 19707290, Free PMC Article
  4. Regulation of activity in vitro and in vivo of three phospholipases B from Saccharomyces cerevisiae. Merkel O, et al. Biochem J, 2005 Apr 15. PMID 15588231, Free PMC Article
  5. Cloning of CnLYSO1, a novel extracellular lysophospholipase of the pathogenic fungus Cryptococcus neoformans. Coe JG, et al. Gene, 2003 Oct 16. PMID 14563553

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables lysophospholipase activity IEA
Inferred from Electronic Annotation
more info
  
enables lysophospholipase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables phosphatidyl phospholipase B activity IEA
Inferred from Electronic Annotation
more info
  
enables phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glycerophospholipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphatidylinositol metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylserine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphatidylserine catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phospholipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in fungal-type vacuole HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lysophospholipase
NP_014632.1
  • Phospholipase B (lysophospholipase) involved in lipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro; PLB3 has a paralog, PLB1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    305349..307409
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183265.1 → NP_014632.1  TPA: lysophospholipase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014632.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W256, Q08108
    UniProtKB/TrEMBL
    A6ZNJ5, B3LJ45
    Conserved Domains (1) summary
    cd07203
    Location:35 → 595
    cPLA2_Fungal_PLB; Fungal Phospholipase B-like; cPLA2 GrpIVA homologs; catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08108.1

Gene LinkOut

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