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GLO4 hydroxyacylglutathione hydrolase GLO4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854205, updated on 13-Apr-2024

Summary

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Gene symbol
GLO4
Gene description
hydroxyacylglutathione hydrolase GLO4
Primary source
SGD:S000005566
Locus tag
YOR040W
See related
AllianceGenome:SGD:S000005566
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables hydroxyacylglutathione hydrolase activity. Involved in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione. Located in mitochondrial matrix. Human ortholog(s) of this gene implicated in paroxysmal nonkinesigenic dyskinesia 1. Orthologous to several human genes including HAGH (hydroxyacylglutathione hydrolase) and HAGHL (hydroxyacylglutathione hydrolase like). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (407064..407921)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Hir2p Neighboring gene casein kinase 2 regulatory subunit CKB2 Neighboring gene ncRNA Neighboring gene ubiquitin-binding protein CUE5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Heterologous expression, purification, and kinetic comparison of the cytoplasmic and mitochondrial glyoxalase II enzymes, Glo2p and Glo4p, from Saccharomyces cerevisiae. Bito A, et al. Protein Expr Purif, 1999 Dec. PMID 10600466
  2. Identification and phenotypic analysis of two glyoxalase II encoding genes from Saccharomyces cerevisiae, GLO2 and GLO4, and intracellular localization of the corresponding proteins. Bito A, et al. J Biol Chem, 1997 Aug 22. PMID 9261170
  3. Assessment of chronological lifespan dependent molecular damages in yeast lacking mitochondrial antioxidant genes. Demir AB, et al. Biochem Biophys Res Commun, 2010 Sep 10. PMID 20707985
  4. Recurrent background mutations in WHI2 impair proteostasis and degradation of misfolded cytosolic proteins in Saccharomyces cerevisiae. Comyn SA, et al. Sci Rep, 2017 Jun 23. PMID 28646136, Free PMC Article
  5. Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein. Willingham S, et al. Science, 2003 Dec 5. PMID 14657499

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydroxyacylglutathione hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydroxyacylglutathione hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydroxyacylglutathione hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydroxyacylglutathione hydrolase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables hydroxyacylglutathione hydrolase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
hydroxyacylglutathione hydrolase GLO4
NP_014683.1
  • Mitochondrial glyoxalase II; catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate; GLO4 has a paralog, GLO2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    407064..407921
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183459.1 → NP_014683.1  TPA: hydroxyacylglutathione hydrolase GLO4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014683.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2A7, Q12320
    UniProtKB/TrEMBL
    A0A8H4BUS9, A6ZNP6, B3LJ93, B5VRU1, C7GLG9, C8ZI02, G2WMS2, N1NVR2
    Conserved Domains (2) summary
    cd07723
    Location:18 → 198
    hydroxyacylglutathione_hydrolase_MBL-fold; hydroxyacylglutathione hydrolase, MBL-fold metallo-hydrolase domain
    pfam16123
    Location:199 → 283
    HAGH_C; Hydroxyacylglutathione hydrolase C-terminus
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12320.1

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