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CYT1 ubiquinol--cytochrome-c reductase catalytic subunit CYT1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854231, updated on 13-Apr-2024

Summary

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Gene symbol
CYT1
Gene description
ubiquinol--cytochrome-c reductase catalytic subunit CYT1
Primary source
SGD:S000005591
Locus tag
YOR065W
See related
AllianceGenome:SGD:S000005591
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CTC1; YOR29-16
Summary
Enables ubiquinol-cytochrome-c reductase activity. Involved in mitochondrial electron transport, ubiquinol to cytochrome c. Located in mitochondrion. Part of mitochondrial respiratory chain complex III. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 6. Orthologous to human CYC1 (cytochrome c1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (447439..448368)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L3 Neighboring gene Yng1p Neighboring gene Msa1p Neighboring gene dolichyl-P-Glc:Glc1Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Metabolic fate of the increased yeast amino Acid uptake subsequent to catabolite derepression. Hothersall JS, et al. J Amino Acids, 2013. PMID 23431419, Free PMC Article
  2. Role of Arg-166 in yeast cytochrome C1. Ahmad Z, et al. J Biol Chem, 2001 May 25. PMID 11279090
  3. Sequencing of the nuclear gene for the yeast cytochrome c1 precursor reveals an unusually complex amino-terminal presequence. Sadler I, et al. EMBO J, 1984 Sep. PMID 6092058, Free PMC Article
  4. Transport of proteins to the mitochondrial intermembrane space: the 'matrix-targeting' and the 'sorting' domains in the cytochrome c1 presequence. van Loon AP, et al. EMBO J, 1987 Aug. PMID 2822392, Free PMC Article
  5. Regulation of the yeast CYT1 gene encoding cytochrome c1 by HAP1 and HAP2/3/4. Schneider JC, et al. Mol Cell Biol, 1991 Oct. PMID 1656218, Free PMC Article

See all (140) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mutational analysis of the Qi-site proton pathway in yeast cytochrome bc1 complex.
    Title: Mutational analysis of the Q(i)-site proton pathway in yeast cytochrome bc(1) complex.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables electron transfer activity IEA
Inferred from Electronic Annotation
more info
  
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquinol-cytochrome-c reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquinol-cytochrome-c reductase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial electron transport, ubiquinol to cytochrome c IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial electron transport, ubiquinol to cytochrome c IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
part_of mitochondrial respiratory chain complex III IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial respiratory chain complex III IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in respirasome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ubiquinol--cytochrome-c reductase catalytic subunit CYT1
NP_014708.1
  • Cytochrome c1; component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    447439..448368
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183484.1 → NP_014708.1  TPA: ubiquinol--cytochrome-c reductase catalytic subunit CYT1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014708.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2C8, P07143
    UniProtKB/TrEMBL
    A0A1L4AA21, A0A5B9RH60, A0A5B9RJN9, A6ZNR7, B3LJB4, B5VRW3, C7GX53, N1NWH9
    Conserved Domains (1) summary
    pfam02167
    Location:76 → 295
    Cytochrom_C1; Cytochrome C1 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P07143.1

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