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KTR1 alpha-1,2-mannosyltransferase KTR1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854266, updated on 13-Apr-2024

Summary

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Gene symbol
KTR1
Gene description
alpha-1,2-mannosyltransferase KTR1
Primary source
SGD:S000005625
Locus tag
YOR099W
See related
AllianceGenome:SGD:S000005625
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables alpha-1,2-mannosyltransferase activity. Involved in protein N-linked glycosylation and protein O-linked glycosylation. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (511825..513006)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene FG-nucleoporin NUP1 Neighboring gene carnitine:acyl carnitine antiporter Neighboring gene Ras family GTPase RAS1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ktr1p is an alpha-1,2-mannosyltransferase of Saccharomyces cerevisiae. Comparison of the enzymic properties of soluble recombinant Ktr1p and Kre2p/Mnt1p produced in Pichia pastoris. Romero PA, et al. Biochem J, 1997 Jan 15. PMID 9020857, Free PMC Article
  2. The Ktr1p, Ktr3p, and Kre2p/Mnt1p mannosyltransferases participate in the elaboration of yeast O- and N-linked carbohydrate chains. Lussier M, et al. J Biol Chem, 1997 Jun 13. PMID 9182588
  3. Completion of the Saccharomyces cerevisiae genome sequence allows identification of KTR5, KTR6 and KTR7 and definition of the nine-membered KRE2/MNT1 mannosyltransferase gene family in this organism. Lussier M, et al. Yeast, 1997 Mar 15. PMID 9090056
  4. Functional characterization of the YUR1, KTR1, and KTR2 genes as members of the yeast KRE2/MNT1 mannosyltransferase gene family. Lussier M, et al. J Biol Chem, 1996 May 3. PMID 8631921
  5. Distinct adaptor proteins assist exit of Kre2-family proteins from the yeast ER. Noda Y, et al. Biol Open, 2014 Mar 15. PMID 24585773, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables alpha-1,2-mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-1,2-mannosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alpha-1,2-mannosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables hexosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables mannosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell wall mannoprotein biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycoprotein biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in mannosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein N-linked glycosylation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-linked glycosylation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in fungal-type vacuole HDA PubMed 
located_in fungal-type vacuole membrane HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alpha-1,2-mannosyltransferase KTR1
NP_014742.1
  • Alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family; relocalizes from vacuole to cytoplasm upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    511825..513006
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183518.1 → NP_014742.1  TPA: alpha-1,2-mannosyltransferase KTR1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014742.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2G0, P27810
    UniProtKB/TrEMBL
    A0A6A5Q7H5, A6ZNU9, B3LJE5, G2WMX6, N1NWY1
    Conserved Domains (1) summary
    COG5020
    Location:1 → 389
    KTR1; Mannosyltransferase [Carbohydrate transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P27810.1

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