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CRC1 carnitine:acyl carnitine antiporter [ Saccharomyces cerevisiae S288C ]

Gene ID: 854267, updated on 17-May-2024

Summary

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Gene symbol
CRC1
Gene description
carnitine:acyl carnitine antiporter
Primary source
FungiDB:YOR100C
Locus tag
YOR100C
See related
SGD:S000005626; AllianceGenome:SGD:S000005626
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables carnitine:acyl carnitine antiporter activity. Involved in fatty acid metabolic process. Located in mitochondrial inner membrane. Used to study lipid metabolism disorder. Human ortholog(s) of this gene implicated in carnitine-acylcarnitine translocase deficiency. Orthologous to human SLC25A20 (solute carrier family 25 member 20). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (513295..514278, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene FG-nucleoporin NUP1 Neighboring gene alpha-1,2-mannosyltransferase KTR1 Neighboring gene Ras family GTPase RAS1 Neighboring gene dolichyl-diphosphooligosaccharide-protein glycotransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional analysis of mutant human carnitine acylcarnitine translocases in yeast. IJlst L, et al. Biochem Biophys Res Commun, 2001 Jan 26. PMID 11162577
  2. Identification of the mitochondrial carnitine carrier in Saccharomyces cerevisiae. Palmieri L, et al. FEBS Lett, 1999 Dec 3. PMID 10622748
  3. dif-1 and colt, both implicated in early embryonic development, encode carnitine acylcarnitine translocase. Oey NA, et al. Mol Genet Metab, 2005 Jun. PMID 15896656
  4. Molecular characterization of carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria in Saccharomyces cerevisiae and identification of a plasma membrane carnitine transporter, Agp2p. van Roermund CW, et al. EMBO J, 1999 Nov 1. PMID 10545096, Free PMC Article
  5. Differential regulation of mitochondrial pyruvate carrier genes modulates respiratory capacity and stress tolerance in yeast. Timón-Gómez A, et al. PLoS One, 2013. PMID 24244496, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables acyl carnitine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carnitine:acyl carnitine antiporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in acyl carnitine transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in carnitine transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in carnitine transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fatty acid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitochondrial transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
carnitine:acyl carnitine antiporter
NP_014743.1
  • Mitochondrial inner membrane carnitine transporter; required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation; human homolog SLC25A20 complements yeast null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    513295..514278 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183519.1 → NP_014743.1  TPA: carnitine:acyl carnitine antiporter [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014743.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2G1, Q12289
    UniProtKB/TrEMBL
    A0A8H4BV50, A6ZNV0, B3LJE6, C7GMN4, G2WMX7, N1NYD9
    Conserved Domains (1) summary
    pfam00153
    Location:137 → 222
    Mito_carr; Mitochondrial carrier protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12289.1

Gene LinkOut

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