THI80 thiamine diphosphokinase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: THI80
Gene description: thiamine diphosphokinase
Primary source: SGD:S000005669
Locus tag: YOR143C
See related: AllianceGenome:SGD:S000005669
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables thiamine diphosphokinase activity. Involved in thiamine diphosphate biosynthetic process. Located in cytoplasm. Used to study cancer. Human ortholog(s) of this gene implicated in inherited metabolic disorder. Orthologous to human TPK1 (thiamin pyrophosphokinase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See THI80 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (601383..602342, complement)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables thiamine binding	IEA Inferred from Electronic Annotation more info
enables thiamine diphosphokinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables thiamine diphosphokinase activity	IDA Inferred from Direct Assay more info	PubMed
enables thiamine diphosphokinase activity	IEA Inferred from Electronic Annotation more info
enables thiamine diphosphokinase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in thiamine diphosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in thiamine diphosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in thiamine diphosphate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in thiamine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in thiamine-containing compound metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed

General protein information

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Preferred Names: thiamine diphosphokinase

NP_014786.1

EC 2.7.6.2

Thiamine pyrophosphokinase; phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

601383..602342 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183562.1 → NP_014786.1 TPA: thiamine diphosphokinase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014786.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W2K1, P35202

UniProtKB/TrEMBL

A0A8H4BW84, C7GN80, G2WN16, N1NWN0

Conserved Domains (1) summary

COG1564
Location:38 → 314

ThiN; Thiamine pyrophosphokinase [Coenzyme transport and metabolism]