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NPT1 nicotinate phosphoribosyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 854384, updated on 7-Apr-2024

Summary

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Gene symbol
NPT1
Gene description
nicotinate phosphoribosyltransferase
Primary source
SGD:S000005735
Locus tag
YOR209C
See related
AllianceGenome:SGD:S000005735
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables nicotinate phosphoribosyltransferase activity. Involved in nicotinate nucleotide salvage; rDNA heterochromatin assembly; and subtelomeric heterochromatin assembly. Located in nucleus. Orthologous to human NAPRT (nicotinate phosphoribosyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (736437..737726, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene DNA-directed RNA polymerase III core subunit RET1 Neighboring gene tyrosine protein phosphatase PTP2 Neighboring gene DNA-directed RNA polymerase core subunit RPB10 Neighboring gene dynamin-related GTPase MGM1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The structure of a eukaryotic nicotinic acid phosphoribosyltransferase reveals structural heterogeneity among type II PRTases. Chappie JS, et al. Structure, 2005 Sep. PMID 16154095
  2. Conversion of a cosubstrate to an inhibitor: phosphorylation mutants of nicotinic acid phosphoribosyltransferase. Rajavel M, et al. Biochemistry, 1998 Mar 24. PMID 9521740
  3. Kinetic analysis of nicotinate phosphoribosyltransferase from yeast using high pressure liquid chromatography. Hanna LS, et al. J Biol Chem, 1983 Aug 25. PMID 6224784
  4. Quantitation of NAD+ biosynthesis from the salvage pathway in Saccharomyces cerevisiae. Sporty J, et al. Yeast, 2009 Jul. PMID 19399913, Free PMC Article
  5. Nicotinamide Suppresses the DNA Damage Sensitivity of Saccharomyces cerevisiae Independently of Sirtuin Deacetylases. Rössl A, et al. Genetics, 2016 Oct. PMID 27527516, Free PMC Article

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The structure of NPT1 at 1.75 A resolution was reported.
    Title: The structure of a eukaryotic nicotinic acid phosphoribosyltransferase reveals structural heterogeneity among type II PRTases.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nicotinate phosphoribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nicotinate phosphoribosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nicotinate phosphoribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in NAD biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in NAD salvage IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nicotinate nucleotide salvage IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in pyridine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in rDNA heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in subtelomeric heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nicotinate phosphoribosyltransferase
NP_014852.1
  • Nicotinate phosphoribosyltransferase; acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    736437..737726 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183628.1 → NP_014852.1  TPA: nicotinate phosphoribosyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014852.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2R5, P39683, Q08626
    UniProtKB/TrEMBL
    A0A8H4F7I6, B5VS92, C7GWH3, C8ZGW5, N1NWS2
    Conserved Domains (1) summary
    TIGR01514
    Location:5 → 416
    NAPRTase; nicotinate phosphoribosyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39683.3

Gene LinkOut

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