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MCT1 [acyl-carrier-protein] S-malonyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 854396, updated on 13-Apr-2024

Summary

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Gene symbol
MCT1
Gene description
[acyl-carrier-protein] S-malonyltransferase
Primary source
SGD:S000005747
Locus tag
YOR221C
See related
AllianceGenome:SGD:S000005747
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables [acyl-carrier-protein] S-malonyltransferase activity. Involved in fatty acid metabolic process. Located in mitochondrion. Orthologous to human MCAT (malonyl-CoA-acyl carrier protein transacylase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (756476..757558, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Ste13p Neighboring gene Rcn2p Neighboring gene mitochondrial 2-oxodicarboxylate carrier Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Physiological function of mycobacterial mtFabD, an essential malonyl-CoA:AcpM transacylase of type 2 fatty acid synthase FASII, in yeast mct1Delta cells. Gurvitz A. Comp Funct Genomics, 2009. PMID 19859569, Free PMC Article
  2. Two genes of the putative mitochondrial fatty acid synthase in the genome of Saccharomyces cerevisiae. Schneider R, et al. Curr Genet, 1997 Dec. PMID 9388293
  3. Requirements for Carnitine Shuttle-Mediated Translocation of Mitochondrial Acetyl Moieties to the Yeast Cytosol. van Rossum HM, et al. mBio, 2016 May 3. PMID 27143389, Free PMC Article
  4. Intersection of RNA processing and the type II fatty acid synthesis pathway in yeast mitochondria. Schonauer MS, et al. Mol Cell Biol, 2008 Nov. PMID 18779316, Free PMC Article
  5. ACP Acylation Is an Acetyl-CoA-Dependent Modification Required for Electron Transport Chain Assembly. Van Vranken JG, et al. Mol Cell, 2018 Aug 16. PMID 30118679, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables [acyl-carrier-protein] S-malonyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables [acyl-carrier-protein] S-malonyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables [acyl-carrier-protein] S-malonyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
[acyl-carrier-protein] S-malonyltransferase
NP_014864.4
  • Predicted malonyl-CoA:ACP transferase; putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    756476..757558 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183640.3 → NP_014864.4  TPA: [acyl-carrier-protein] S-malonyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014864.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2S6, Q12283
    UniProtKB/TrEMBL
    A0A8H4BV21, B3LJP4, B5VSA3, C7GWG2, C8ZGX5, N1NX75
    Conserved Domains (1) summary
    COG0331
    Location:6 → 350
    FabD; Malonyl CoA-acyl carrier protein transacylase [Lipid transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12283.2

Gene LinkOut

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