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PMT3 dolichyl-phosphate-mannose-protein mannosyltransferase PMT3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854499, updated on 11-Apr-2024

Summary

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Gene symbol
PMT3
Gene description
dolichyl-phosphate-mannose-protein mannosyltransferase PMT3
Primary source
SGD:S000005848
Locus tag
YOR321W
See related
AllianceGenome:SGD:S000005848
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable dolichyl-phosphate-mannose-protein mannosyltransferase activity. Involved in protein O-linked mannosylation. Located in endoplasmic reticulum. Part of dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt3p dimer complex and dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt3p dimer complex. Human ortholog(s) of this gene implicated in lissencephaly and muscular dystrophy (multiple). Orthologous to human POMT2 (protein O-mannosyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (916030..918291)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene U2 snRNP complex subunit HSH49 Neighboring gene glucose N-acetyltransferase Neighboring gene Ldb19p Neighboring gene glutamate-5-semialdehyde dehydrogenase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional implications of MIR domains in protein O-mannosylation. Chiapparino A, et al. Elife, 2020 Dec 24. PMID 33357379, Free PMC Article
  2. A conserved acidic motif is crucial for enzymatic activity of protein O-mannosyltransferases. Lommel M, et al. J Biol Chem, 2011 Nov 18. PMID 21956107, Free PMC Article
  3. PMT3 and PMT4, two new members of the protein-O-mannosyltransferase gene family of Saccharomyces cerevisiae. Immervoll T, et al. Yeast, 1995 Nov. PMID 8585318
  4. Members of the evolutionarily conserved PMT family of protein O-mannosyltransferases form distinct protein complexes among themselves. Girrbach V, et al. J Biol Chem, 2003 Apr 4. PMID 12551906
  5. Protein-O-glycosylation in yeast: protein-specific mannosyltransferases. Gentzsch M, et al. Glycobiology, 1997 Jun. PMID 9184828

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables dolichyl-phosphate-mannose-protein mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dolichyl-phosphate-mannose-protein mannosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables dolichyl-phosphate-mannose-protein mannosyltransferase activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables mannosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein O-linked glycosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein O-linked glycosylation ISA
Inferred from Sequence Alignment
more info
 PubMed 
involved_in protein O-linked mannosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-linked mannosylation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt3p dimer complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt3p dimer complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dolichyl-phosphate-mannose-protein mannosyltransferase PMT3
NP_014966.1
  • Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; antifungal drug target; PMT3 has a paralog, PMT2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    916030..918291
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183741.1 → NP_014966.1  TPA: dolichyl-phosphate-mannose-protein mannosyltransferase PMT3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014966.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W319, P47190
    UniProtKB/TrEMBL
    A0A8H4BXE1, A6ZPF4, C7GNU2, C8ZH72, N1NYY4
    Conserved Domains (1) summary
    COG1928
    Location:31 → 750
    PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47190.2

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