ALA1 alanine--tRNA ligase [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: ALA1
Gene description: alanine--tRNA ligase
Primary source: SGD:S000005862
Locus tag: YOR335C
See related: AllianceGenome:SGD:S000005862
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CDC64
Summary: Enables alanine-tRNA ligase activity. Involved in alanyl-tRNA aminoacylation. Located in mitochondrion. Used to study Charcot-Marie-Tooth disease; axonal neuropathy; cerebellar ataxia; and dermatomyositis. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2N; combined oxidative phosphorylation deficiency 8; and developmental and epileptic encephalopathy 29. Orthologous to several human genes including AARS1 (alanyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables alanine-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alanine-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables alanine-tRNA ligase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables aminoacyl-tRNA editing activity	IBA Inferred from Biological aspect of Ancestor more info
enables aminoacyl-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables tRNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in alanyl-tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in alanyl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info
involved_in alanyl-tRNA aminoacylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in aminoacyl-tRNA metabolism involved in translational fidelity	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial alanyl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info
involved_in protein metabolic process	IEA Inferred from Electronic Annotation more info
involved_in translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

NP_014980.3

Cytoplasmic and mitochondrial alanyl-tRNA synthetase; required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog AARS; mutations in human homolog AARS are associated with autoimmune disease polymyositis/dermatomyositis and with hereditary peripheral neuropathy, Charcot-Marie-Tooth (CMT) disease