PDE2 3',5'-cyclic-nucleotide phosphodiesterase PDE2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: PDE2
Gene description: 3',5'-cyclic-nucleotide phosphodiesterase PDE2
Primary source: SGD:S000005887
Locus tag: YOR360C
See related: AllianceGenome:SGD:S000005887
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: SRA5
Summary: Enables 3',5'-cyclic-AMP phosphodiesterase activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 74 and primary pigmented nodular adrenocortical disease. Orthologous to several human genes including PDE8A (phosphodiesterase 8A); PDE8B (phosphodiesterase 8B); and PDE9A (phosphodiesterase 9A). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See PDE2 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (1013241..1014821, complement)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Crosstalk between protein kinase A and the HOG pathway under impaired biosynthesis of complex sphingolipids in budding yeast.
Title: Crosstalk between protein kinase A and the HOG pathway under impaired biosynthesis of complex sphingolipids in budding yeast.
The overexpressed genes, YAP1, PDE2, and STB3, can enhance the tolerance of yeast cells to 7-chlorotetrazolo[5,1-c]benzo[1,2,4]triazine.
Title: Overexpression of the YAP1, PDE2, and STB3 genes enhances the tolerance of yeast to oxidative stress induced by 7-chlorotetrazolo[5,1-c]benzo[1,2,4]triazine.
Both SSD1 and PDE2 seemed to improve ethanol tolerance by maintaining robustness of the yeast cell wall.
Title: Overexpression of PDE2 or SSD1-V in Saccharomyces cerevisiae W303-1A strain renders it ethanol-tolerant.
These results suggest that, like its low-affinity counterpart, the high-affinity phosphodiesterase may also play an important role in the PKA-controlled feedback inhibition of intracellular cAMP.
Title: The localization and concentration of the PDE2-encoded high-affinity cAMP phosphodiesterase is regulated by cAMP-dependent protein kinase A in the yeast Saccharomyces cerevisiae.
VEGF increased cAMP-hydrolytic activity by up-regulating the expression of PDE2 and PDE4 isozymes
Title: Modulation of VEGF-induced endothelial cell cycle protein expression through cyclic AMP hydrolysis by PDE2 and PDE4.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3',5'-cyclic-AMP phosphodiesterase activity	IDA Inferred from Direct Assay more info	PubMed
enables 3',5'-cyclic-AMP phosphodiesterase activity	IEA Inferred from Electronic Annotation more info
enables 3',5'-cyclic-GMP phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3',5'-cyclic-nucleotide phosphodiesterase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cAMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: 3',5'-cyclic-nucleotide phosphodiesterase PDE2

NP_015005.1

EC 3.1.4.53

High-affinity cyclic AMP phosphodiesterase; component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

1013241..1014821 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183780.1 → NP_015005.1 TPA: 3',5'-cyclic-nucleotide phosphodiesterase PDE2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015005.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W355, P06776, Q08836

UniProtKB/TrEMBL

A0A6A5Q6P9, A6ZPJ0, B3LK17, B5VSN8, C7GNQ8, G2WNM1, N1NW97

Conserved Domains (1) summary

pfam00233
Location:264 → 513

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase