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FDH1 formate dehydrogenase (NAD+) [ Saccharomyces cerevisiae S288C ]

Gene ID: 854570, updated on 11-Apr-2024

Summary

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Gene symbol
FDH1
Gene description
formate dehydrogenase (NAD+)
Primary source
SGD:S000005915
Locus tag
YOR388C
See related
AllianceGenome:SGD:S000005915
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables formate dehydrogenase (NAD+) activity. Involved in formate catabolic process. Located in cytosol. Human ortholog(s) of this gene implicated in primary hyperoxaluria and primary hyperoxaluria type 2. Orthologous to human GRHPR (glyoxylate and hydroxypyruvate reductase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (1071793..1072923, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene deoxyribodipyrimidine photo-lyase PHR1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene fluoride transporter

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Engineering of coenzyme specificity of formate dehydrogenase from Saccharomyces cerevisiae. Serov AE, et al. Biochem J, 2002 Nov 1. PMID 12144528, Free PMC Article
  2. Regulation and evaluation of five methanol-inducible promoters in the methylotrophic yeast Candida boidinii. Yurimoto H, et al. Biochim Biophys Acta, 2000 Sep 7. PMID 10978507
  3. Functional analysis of structural genes for NAD(+)-dependent formate dehydrogenase in Saccharomyces cerevisiae. Overkamp KM, et al. Yeast, 2002 Apr. PMID 11921099
  4. Systems-level engineering of nonfermentative metabolism in yeast. Kennedy CJ, et al. Genetics, 2009 Sep. PMID 19564482, Free PMC Article
  5. Efficient fermentation of xylose to ethanol at high formic acid concentrations by metabolically engineered Saccharomyces cerevisiae. Hasunuma T, et al. Appl Microbiol Biotechnol, 2011 May. PMID 21246355

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables formate dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables formate dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables formate dehydrogenase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in formate catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in formate catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
formate dehydrogenase (NAD+)
NP_015033.1
  • NAD(+)-dependent formate dehydrogenase; may protect cells from exogenous formate

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    1071793..1072923 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183808.1 → NP_015033.1  TPA: formate dehydrogenase (NAD+) [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015033.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZN46, C8ZHD6, D6W381, N1P3Y5, P0CT22, Q08911
    UniProtKB/TrEMBL
    A0A6A5Q8I8, G2WNP8
    Conserved Domains (1) summary
    cd05302
    Location:4 → 371
    FDH; NAD-dependent Formate Dehydrogenase (FDH)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08911.1

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