COB cytochrome b [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: COB
Gene description: cytochrome b
Primary source: FungiDB:Q0105
Locus tag: Q0105
See related: SGD:S000007270; AllianceGenome:SGD:S000007270
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Saccharomyces cerevisiae S288C (strain: S288C, substrain: FY1679)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: COB1; CYTB
Summary: Enables ubiquinol-cytochrome-c reductase activity. Involved in mitochondrial electron transport, ubiquinol to cytochrome c. Located in mitochondrion. Part of mitochondrial respiratory chain complex III. Human ortholog(s) of this gene implicated in ovarian carcinoma and urinary bladder cancer. Orthologous to human MT-CYB (mitochondrially encoded cytochrome b). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See COB in Genome Data Viewer

Sequence:: Chromosome: MT; NC_001224.1 (36540..43647)

Chromosome MT - NC_001224.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001224.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The cytochrome b carboxyl terminal region is necessary for mitochondrial complex III assembly.
Title: The cytochrome b carboxyl terminal region is necessary for mitochondrial complex III assembly.
Overexpression of MRX9 impairs processing of RNAs encoding mitochondrial oxidative phosphorylation factors COB and COX1 in yeast.
Title: Overexpression of MRX9 impairs processing of RNAs encoding mitochondrial oxidative phosphorylation factors COB and COX1 in yeast.
Mutational analysis of the Qi-site proton pathway in yeast cytochrome bc1 complex.
Title: Mutational analysis of the Q(i)-site proton pathway in yeast cytochrome bc(1) complex.
Here, we unravel the sequence of events in the mitochondrial inner membrane by which cytochrome b is hemylated.
Title: Assembly factors monitor sequential hemylation of cytochrome b to regulate mitochondrial translation.
Ccm1p/Ygr150cp is essential to remove the fourth intron of COB pre-mRNAs in Saccharomyces cerevisiae.
Title: Ccm1p/Ygr150cp, a pentatricopeptide repeat protein, is essential to remove the fourth intron of both COB and COX1 pre-mRNAs in Saccharomyces cerevisiae.
there is a pathway for structural communication between the two active sites of cytochrome b and open new possibilities for the utilization of center N as a potential drug target.
Title: Combining Inhibitor Resistance-conferring Mutations in Cytochrome b Creates Conditional Synthetic Lethality in Saccharomyces cerevisiae.
E272 residue may not be involved in direct substrate binding or in its direct deprotonation.
Title: Is cytochrome b glutamic acid 272 a quinol binding residue in the bc1 complex of Saccharomyces cerevisiae?
Altered kinetics at center N (where uiquinone is re-reduced) and activation of ubiquinol oxidation by binding of cytochrome c in the mutant Tyr132Phe and Glu272Asp enzymes indicate long range effects of these mutations.
Title: Mutational analysis of cytochrome b at the ubiquinol oxidation site of yeast complex III.
analysis of electron transfer between monomers when the cytochrome bc1 complex dimer is reduced through center N
Title: Rapid electron transfer between monomers when the cytochrome bc1 complex dimer is reduced through center N.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
contributes_to ubiquinol-cytochrome-c reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquinol-cytochrome-c reductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in aerobic respiration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial electron transport, ubiquinol to cytochrome c	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial electron transport, ubiquinol to cytochrome c	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in respiratory electron transport chain	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
part_of mitochondrial respiratory chain complex III	IBA Inferred from Biological aspect of Ancestor more info
part_of mitochondrial respiratory chain complex III	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in respirasome	IEA Inferred from Electronic Annotation more info
part_of respiratory chain complex III	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytochrome b

NP_009315.1

EC 7.1.1.8

Cytochrome b; mitochondrially-encoded subunit of ubiquinol-cytochrome c reductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p; number of introns varies between strains from 0 to 6, with most having 5