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HIS5 histidinol-phosphate transaminase [ Saccharomyces cerevisiae S288C ]

Gene ID: 854690, updated on 17-May-2024

Summary

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Gene symbol
HIS5
Gene description
histidinol-phosphate transaminase
Primary source
FungiDB:YIL116W
Locus tag
YIL116W
See related
SGD:S000001378; AllianceGenome:SGD:S000001378
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables histidinol-phosphate transaminase activity. Involved in histidine biosynthetic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (142928..144085)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Rho family GTPase RHO3 Neighboring gene pheromone-regulated protein PRM5 Neighboring gene FG-nucleoporin NUP159 Neighboring gene putative porin POR2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning of the HIS5 gene of Saccharomyces cerevisiae by yeast transformation. Harashima S, et al. Gene, 1981 Dec. PMID 7044894
  2. Structure of the yeast HIS5 gene responsive to general control of amino acid biosynthesis. Nishiwaki K, et al. Mol Gen Genet, 1987 Jun. PMID 3302607
  3. GENE-ENZYME RELATIONS IN HISTIDINE BIOSYNTHESIS IN YEAST. FINK GR. Science, 1964 Oct 23. PMID 14190241
  4. Toxicity of copper, cobalt, and nickel salts is dependent on histidine metabolism in the yeast Saccharomyces cerevisiae. Pearce DA, et al. J Bacteriol, 1999 Aug. PMID 10438744, Free PMC Article
  5. Enrichment-Based Proteogenomics Identifies Microproteins, Missing Proteins, and Novel smORFs in Saccharomyces cerevisiae. He C, et al. J Proteome Res, 2018 Jul 6. PMID 29897761

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables histidinol-phosphate transaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables histidinol-phosphate transaminase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables transaminase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in histidine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in histidine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 

General protein information

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Preferred Names
histidinol-phosphate transaminase
NP_012150.1
  • Histidinol-phosphate aminotransferase; catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    142928..144085
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179464.1 → NP_012150.1  TPA: histidinol-phosphate transaminase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012150.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVH1, P07172
    UniProtKB/TrEMBL
    A0A8H4C087, A6ZVG1, B3LTW3, B5VKJ3, C8ZAC8, G2WG35, N1P1X8
    Conserved Domains (1) summary
    TIGR01141
    Location:10 → 377
    hisC; histidinol-phosphate aminotransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P07172.2

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