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COX5B cytochrome c oxidase subunit Vb [ Saccharomyces cerevisiae S288C ]

Gene ID: 854695, updated on 13-Apr-2024

Summary

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Gene symbol
COX5B
Gene description
cytochrome c oxidase subunit Vb
Primary source
SGD:S000001373
Locus tag
YIL111W
See related
AllianceGenome:SGD:S000001373
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to cytochrome-c oxidase activity and nitrite reductase (NO-forming) activity. Involved in mitochondrial electron transport, cytochrome c to oxygen. Located in mitochondrion. Part of mitochondrial respiratory chain complex IV. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease. Orthologous to human COX4I1 (cytochrome c oxidase subunit 4I1) and COX4I2 (cytochrome c oxidase subunit 4I2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IX
Exon count:
2
Sequence:
Chromosome: IX; NC_001141.2 (155222..155765)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase tyrosine protein phosphatase SDP1 Neighboring gene Hos4p Neighboring gene protein-histidine N-methyltransferase Neighboring gene COPII subunit SEC24

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Two nonidentical forms of subunit V are functional in yeast cytochrome c oxidase. Cumsky MG, et al. Proc Natl Acad Sci U S A, 1985 Apr. PMID 2986105, Free PMC Article
  2. Differential effectiveness of yeast cytochrome c oxidase subunit genes results from differences in expression not function. Trueblood CE, et al. Mol Cell Biol, 1987 Oct. PMID 2824990, Free PMC Article
  3. Structural analysis of two genes encoding divergent forms of yeast cytochrome c oxidase subunit V. Cumsky MG, et al. Mol Cell Biol, 1987 Oct. PMID 2824989, Free PMC Article
  4. Comparisons of subunit 5A and 5B isoenzymes of yeast cytochrome c oxidase. Dodia R, et al. Biochem J, 2014 Dec 15. PMID 25241981, Free PMC Article
  5. Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons. Chung CY, et al. Science, 2013 Nov 22. PMID 24158904, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Comparison of isoenzymes cox5a and cox5b indicate that the elevated activity of cox5b in the rox1 mutant is not caused by exchange of isoforms.
    Title: Comparisons of subunit 5A and 5B isoenzymes of yeast cytochrome c oxidase.
  2. COX5a is switched off and COX5b is switched on when the O2 concentration drops below a threshold of 0.5 microM O2.
    Title: Oxygen-regulated isoforms of cytochrome c oxidase have differential effects on its nitric oxide production and on hypoxic signaling.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial electron transport, cytochrome c to oxygen IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
Inferred from Electronic Annotation
more info
  
involved_in oxidative phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
part_of mitochondrial respiratory chain complex IV IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial respiratory chain complex IV IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mitochondrial respiratory chain complex IV IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytochrome c oxidase subunit Vb
NP_012155.1
  • Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    155222..155765
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179459.1 → NP_012155.1  TPA: cytochrome c oxidase subunit Vb [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012155.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVH6, P00425
    UniProtKB/TrEMBL
    A6ZVG6, C8ZAD4, G2WG41
    Conserved Domains (1) summary
    cd00922
    Location:18 → 151
    Cyt_c_Oxidase_IV; Cytochrome c oxidase subunit IV. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P00425.3

Gene LinkOut

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