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SER33 phosphoglycerate dehydrogenase SER33 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854736, updated on 13-Apr-2024

Summary

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Gene symbol
SER33
Gene description
phosphoglycerate dehydrogenase SER33
Primary source
SGD:S000001336
Locus tag
YIL074C
See related
AllianceGenome:SGD:S000001336
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables alpha-ketoglutarate reductase activity and phosphoglycerate dehydrogenase activity. Involved in serine family amino acid biosynthetic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in Neu-Laxova syndrome 1; PHGDH deficiency; amino acid metabolic disorder; primary hyperoxaluria; and primary hyperoxaluria type 2. Orthologous to human GRHPR (glyoxylate and hydroxypyruvate reductase) and PHGDH (phosphoglycerate dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (221081..222490, complement)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene coatomer subunit epsilon Neighboring gene proteasome regulatory particle base subunit RPN2 Neighboring gene Spo22p Neighboring gene Hop1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. 3-Phosphoglycerate Transhydrogenation Instead of Dehydrogenation Alleviates the Redox State Dependency of Yeast de Novo l-Serine Synthesis. Paczia N, et al. Biochemistry, 2019 Jan 29. PMID 30668112
  2. The SESAME complex regulates cell senescence through the generation of acetyl-CoA. Chen W, et al. Nat Metab, 2021 Jul. PMID 34183849
  3. Linking the dynamics of chromatin occupancy and transcription with predictive models. Tran TQ, et al. Genome Res, 2021 Jun. PMID 33893157, Free PMC Article
  4. NAD(P)HX repair deficiency causes central metabolic perturbations in yeast and human cells. Becker-Kettern J, et al. FEBS J, 2018 Sep. PMID 30098110
  5. Saccharomyces cerevisiae Forms D-2-Hydroxyglutarate and Couples Its Degradation to D-Lactate Formation via a Cytosolic Transhydrogenase. Becker-Kettern J, et al. J Biol Chem, 2016 Mar 18. PMID 26774271, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables alpha-ketoglutarate reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alpha-ketoglutarate reductase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables alpha-ketoglutarate reductase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables phosphoglycerate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoglycerate dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-serine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in carboxylic acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in serine family amino acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 

General protein information

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Preferred Names
phosphoglycerate dehydrogenase SER33
NP_012191.1
  • 3-phosphoglycerate dehydrogenase and alpha-ketoglutarate reductase; 3PG dehydrogenase that catalyzes the first step in serine and glycine biosynthesis; also functions as an alpha-ketoglutarate reductase, converting alpha-ketoglutarate to D-2-hydroxyglutarate (D-2HG); localizes to the cytoplasm; SER33 has a paralog, SER3, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    221081..222490 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179424.1 → NP_012191.1  TPA: phosphoglycerate dehydrogenase SER33 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012191.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVL0, P40510
    UniProtKB/TrEMBL
    A0A8H4BZ61, A0SXJ5, A6ZVJ9, B3LTS5, C7GKK5, C8ZAH1, G2WG74, N1P215
    Conserved Domains (1) summary
    PRK11790
    Location:59 → 469
    PRK11790; phosphoglycerate dehydrogenase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40510.1

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