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CBR1 cytochrome-b5 reductase [ Saccharomyces cerevisiae S288C ]

Gene ID: 854768, updated on 11-Apr-2024

Summary

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Gene symbol
CBR1
Gene description
cytochrome-b5 reductase
Primary source
SGD:S000001305
Locus tag
YIL043C
See related
AllianceGenome:SGD:S000001305
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CBR5
Summary
Enables cytochrome-b5 reductase activity, acting on NAD(P)H. Involved in tRNA wobble uridine modification. Located in mitochondrial outer membrane and nucleus. Human ortholog(s) of this gene implicated in breast cancer and methemoglobinemia. Orthologous to several human genes including CYB5R2 (cytochrome b5 reductase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (274072..274926, complement)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene putative protein phosphatase regulator PIG2 Neighboring gene GTPase-activating protein AGE2 Neighboring gene protein kinase PKP1 Neighboring gene Gvp36p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel mutation of the cytochrome-b5 reductase gene in an Indian patient: the molecular basis of type I methemoglobinemia. Nussenzveig RH, et al. Haematologica, 2006 Nov. PMID 17082011
  2. Isolation and complete sequence of CBR, a gene encoding a putative cytochrome b reductase in Saccharomyces cerevisiae. Csukai M, et al. Eur J Biochem, 1994 Jan 15. PMID 8307010
  3. Studies on the microsomal electron-transport system of anaerobically grown yeast. IV. Purification and characterization of NADH-cytochrome b5 reductase. Kubota S, et al. J Biochem, 1977 Jan. PMID 14930
  4. Activation of the unfolded protein response pathway causes ceramide accumulation in yeast and INS-1E insulinoma cells. Epstein S, et al. J Lipid Res, 2012 Mar. PMID 22210926, Free PMC Article
  5. Proteins involved in sterol synthesis interact with Ste20 and regulate cell polarity. Tiedje C, et al. J Cell Sci, 2007 Oct 15. PMID 17895367

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables cytochrome-b5 reductase activity, acting on NAD(P)H IDA
Inferred from Direct Assay
more info
 PubMed 
enables cytochrome-b5 reductase activity, acting on NAD(P)H IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein histidyl modification to diphthamide IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA wobble uridine modification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial outer membrane HDA PubMed 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cytochrome-b5 reductase
NP_012221.2
  • Cytochrome b reductase and NADH-dependent reductase for Dph3p; required for diphthamide synthesis and tRNA wobble uridine modification; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    274072..274926 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179393.1 → NP_012221.2  TPA: cytochrome-b5 reductase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012221.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVN9, P38626
    UniProtKB/TrEMBL
    A0A8H4C1K7, C8ZAK3, N1P449
    Conserved Domains (1) summary
    cd06183
    Location:43 → 284
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38626.2

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