PRI1 DNA primase subunit PRI1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: PRI1
Gene description: DNA primase subunit PRI1
Primary source: SGD:S000001447
Locus tag: YIR008C
See related: AllianceGenome:SGD:S000001447
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Contributes to DNA primase activity and single-stranded DNA binding activity. Involved in DNA replication, synthesis of RNA primer. Located in nuclear replication fork. Part of alpha DNA polymerase:primase complex. Orthologous to human PRIM1 (DNA primase subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See PRI1 in Genome Data Viewer

Location:: chromosome: IX

Exon count:: 1

Sequence:: Chromosome: IX; NC_001141.2 (373077..374306, complement)

Chromosome IX - NC_001141.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that a defective DNA polymerase alpha (Polalpha)/DNA primase/chromatin-binding protein Ctf4 complex causes unscheduled strand annealing and fork reversal.
Title: Error-free DNA damage tolerance and sister chromatid proximity during DNA replication rely on the Polα/Primase/Ctf4 Complex.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA primase activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA primase activity	IEA Inferred from Electronic Annotation more info
enables DNA primase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables DNA primase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA replication, synthesis of primer	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA replication, synthesis of primer	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA replication, synthesis of primer	IEA Inferred from Electronic Annotation more info
involved_in DNA-templated DNA replication	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of DNA-directed RNA polymerase complex	IEA Inferred from Electronic Annotation more info
part_of alpha DNA polymerase:primase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of alpha DNA polymerase:primase complex	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear replication fork	IDA Inferred from Direct Assay more info	PubMed
part_of primosome complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DNA primase subunit PRI1

NP_012273.1

Subunit of DNA primase; DNA primase is required for DNA synthesis and double-strand break repair

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001141.2 Reference assembly

Range

373077..374306 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179530.1 → NP_012273.1 TPA: DNA primase subunit PRI1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012273.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VVT8, P10363

UniProtKB/TrEMBL

A0A8H4C1R0, A6ZVS7, B3LTK1, C7GJG4, C8ZAQ7, N1P491

Conserved Domains (1) summary

TIGR00335
Location:13 → 362

primase_sml; DNA primase, eukaryotic-type, small subunit, putative