COQ5 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: COQ5
Gene description: 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase
Primary source: FungiDB:YML110C
Locus tag: YML110C
See related: SGD:S000004578; AllianceGenome:SGD:S000004578
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: DBI56
Summary: Enables 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity. Involved in aerobic respiration and ubiquinone biosynthetic process. Located in mitochondrial matrix. Used to study coenzyme Q10 deficiency disease. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 9. Orthologous to human COQ5 (coenzyme Q5, methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (50031..50954, complement)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A putative catalytic mechanism of Coq5 was proposed in which Arg201 acts as a general base to initiate catalysis with the help of a water molecule
Title: Crystal structures and catalytic mechanism of the C-methyltransferase Coq5 provide insights into a key step of the yeast coenzyme Q synthesis pathway.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in aerobic respiration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in ubiquinone biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquinone biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in ubiquinone biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extrinsic component of mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase

NP_013597.1

EC 2.1.1.201

2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; respiratory defect of the null mutant is partially complemented by human COQ5

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

50031..50954 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182472.1 → NP_013597.1 TPA: 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013597.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W0H4, P49017

UniProtKB/TrEMBL

A0A8H4BYD6, A6ZLV4, B3LLE9, C7GV92, C8ZE92, G2WJU6, N1NXB0

Conserved Domains (1) summary

pfam01209
Location:67 → 306

Ubie_methyltran; ubiE/COQ5 methyltransferase family